{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:38:50Z","timestamp":1791070730756,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016061","name":"Stichting de Drie Lichten","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["NNF18OC0052064"],"award-info":[{"award-number":["NNF18OC0052064"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To study the association between femoral neck (FN) bone mineral density (BMD) T\u2010score and fracture risk in individuals with and without type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010centre retrospective cohort study using the Danish National Health Service. BMD of the FN was measured by dual\u2010energy X\u2010ray absorptiometry. Cox proportional hazards regression models were used to study the association between FN BMD T\u2010score and fractures in individuals with and without T2D separately, adjusted for age, comorbidities and comedication. The results from this analysis were used to estimate the 10\u2010year absolute fracture risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, there were 35,129 women (2362 with T2D) and 7069 men (758 with T2D).<\/jats:p>\n                    <jats:p>The FN BMD T\u2010score was significantly associated with risk of any, hip and major osteoporotic fracture in men and women with [adjusted hazard risk ratios (aHR) women, hip: 1.57; 95% confidence interval (CI) 1.24\u20132.00, incidence rate (IR) 8.7; aHR men, hip: 1.55; 95% CI 1.01\u20132.36, IR 4.6] and without T2D (aHR women, hip: 1.75; 95% CI 1.64\u20131.87, IR 7.0; aHR men, hip: 1.97, 95% CI 1.73\u20132.25, IR 6.3), and its ability to predict fracture risk was similar. Fracture IRs were not significantly different for individuals with or without T2D, nor was the estimated cumulative 10\u2010year fracture risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FN BMD T\u2010score was significantly associated with hip, non\u2010spine and major osteoporotic fracture risk in men and women with and without T2D. Fracture risk for a given T\u2010score and age was equal in individuals with and without T2D, as was the ability of the FN BMD T\u2010score to predict fracture risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15890","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:34:59Z","timestamp":1725420899000},"page":"5325-5335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fracture risk revisited: Bone mineral density T\u2010score and fracture risk in type 2 diabetes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-7504","authenticated-orcid":false,"given":"V.","family":"Van Hulten","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Toxicology Maastricht University Medical Centre+ (MUMC+)  Maastricht The Netherlands"},{"name":"School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University  Maastricht The Netherlands"},{"name":"Department of Clinical Pharmacy, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H. M.","family":"Driessen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Toxicology Maastricht University Medical Centre+ (MUMC+)  Maastricht The Netherlands"},{"name":"Department of Clinical Pharmacy, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kvist","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark  Aalborg Denmark"},{"name":"Department of Endocrinology and Metabolism, Molecular Endocrinology &amp; Stem Cell Research Unit (KMEB) Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Viggers","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark  Aalborg Denmark"},{"name":"Department of Endocrinology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bliuc","sequence":"additional","affiliation":[{"name":"Bone Biology Division Garvan Institute of Medical Research  Sydney New South Wales Australia"},{"name":"School of population Health, Faculty of Medicine and Health University of New South Wales Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Center","sequence":"additional","affiliation":[{"name":"Bone Biology Division Garvan Institute of Medical Research  Sydney New South Wales Australia"},{"name":"Clinical School, St Vincent's Hospital, Faculty of Medicine University of New South Wales Sydney  Sydney New South Wales Australia"},{"name":"Department of Endocrinology and Diabetes St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C. J. G.","family":"Brouwers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Maastricht University Medical Centre+ (MUMC+)  Maastricht Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht Netherlands"},{"name":"Care and Public Health Research Institute (CAPHRI) Maastricht University  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark  Aalborg Denmark"},{"name":"Department of Endocrinology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"van den Bergh","sequence":"additional","affiliation":[{"name":"School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University  Maastricht The Netherlands"},{"name":"Department of Internal Medicine, Division of Rheumatology Maastricht University Medical Centre+ (MUMC+)  Maastricht The Netherlands"},{"name":"Department of Internal Medicine, Subdivision of Endocrinology VieCuri Medical Center  Venlo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0253-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2019.231"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00347-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2022.101614"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.832977"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004172"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.715"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"S52","article-title":"4. 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