{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:14:46Z","timestamp":1784261686109,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2021\u2010I2M\u20101\u2010008"],"award-info":[{"award-number":["2021\u2010I2M\u20101\u2010008"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the relationship between the stress\u2010hyperglycaemia ratio (SHR) and the clinical prognosis of patients with moderate\u2010to\u2010severe coronary artery calcification (MSCAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We consecutively enrolled 3841 patients with angiography\u2010detected MSCAC. The individuals were categorized into three groups based on SHR tertiles: T1 (SHR \u2264\u20090.77), T2 (0.77 &lt; SHR \u2264\u20090.89) and T3 (SHR &gt; 0.89). The SHR value was calculated using the formula SHR\u2009=\u2009[admission glucose (mmol\/L)]\/[1.59\u2009\u00d7\u2009HbA1c (%)\u2009\u2212\u20092.59]. The primary outcomes were major adverse cardiovascular and cerebrovascular events (MACCEs), including all\u2010cause death, non\u2010fatal myocardial infarction and non\u2010fatal stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 3.11\u2009years, 241 MACCEs were recorded. Kaplan\u2013Meier survival analysis showed that the SHR T3 group had the highest incidence of MACCEs (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Moreover, findings from the restricted cubic spline analysis showed a significant and positive association between the SHR and MACCEs. This correlation remained consistent even after considering other variables that could potentially impact the results (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>non\u2010linear<\/jats:sub>\n                      \u2009=\u2009.794). When comparing SHR T1 with SHR T3, it was found that SHR T3 was significantly associated with an increased risk of the primary outcome (adjusted hazard ratio\u2009=\u20091.50; 95% confidence interval: 1.10\u20102.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with MSCAC showed a positive correlation between the SHR and MACCE rate over a 3\u2010year follow\u2010up period. The study showed that an SHR value of 0.83 is the key threshold, indicating a poor prognosis. Future large\u2010scale multicentre investigations should be conducted to determine the predictive value of the SHR in patients with MSCAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15894","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T03:54:41Z","timestamp":1724730881000},"page":"4933-4944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic value of the stress\u2010hyperglycaemia ratio in patients with moderate\u2010to\u2010severe coronary artery calcification: Insights from a large cohort study"],"prefix":"10.1111","volume":"26","author":[{"given":"Zhangyu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Cardiometabolic Medicine Center, Fuwai Hospital, 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