{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:52:15Z","timestamp":1790905935366,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of oral semaglutide for type 2 diabetes mellitus (T2DM) in patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This was a single\u2010arm, multicentre, prospective study. Among 80 consecutive patients with MASLD and T2DM who newly received oral semaglutide, 70 completed 48\u2010week oral semaglutide treatment as scheduled and were included in an efficacy analysis. Dose adjustments of oral semaglutide were determined by each physician while monitoring efficacy and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant improvements in body weight, liver enzymes, lipid profile, and glycaemic control were found at 48\u2009weeks compared with baseline values (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Controlled attenuation parameter values significantly decreased from baseline to 48\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Changes in alanine aminotransferase concentrations (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and controlled attenuation parameter values (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) were significantly correlated with changes in body weight. Liver fibrosis markers, such as type IV collagen 7S,\n                      <jats:italic>Wisteria floribunda<\/jats:italic>\n                      agglutinin\u2010positive Mac\u20102\u2010binding protein, fibrosis\u20104 index, and liver stiffness measurement, significantly decreased from baseline to 48\u2009weeks (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The most common adverse events were Grades 1\u20132 transient gastrointestinal symptoms, such as nausea (23 patients, 28.8%), dyspepsia (12, 15.0%) and appetite loss (4, 5.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral semaglutide treatment for T2DM in patients with MASLD leads to an improvement in liver steatosis and injury, surrogate markers of fibrosis, diabetic status, and lipid profile, and reduces body weight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15898","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T01:55:16Z","timestamp":1725328516000},"page":"4958-4965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Beneficial effect of oral semaglutide for type 2 diabetes mellitus in patients with metabolic dysfunction\u2010associated steatotic liver disease: A prospective, multicentre, observational study"],"prefix":"10.1111","volume":"26","author":[{"given":"Taeang","family":"Arai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-7111","authenticated-orcid":false,"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Tsubota","sequence":"additional","affiliation":[{"name":"Core Research Facilities for Basic Science, Research Center for Medical Sciences The Jikei University School of Medicine  Tokyo 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