{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:33Z","timestamp":1772160153257,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the likelihood of mortality or rehospitalization following acute coronary syndrome with glyburide versus gliclazide use in adults with type 2 diabetes undergoing cardiac catheterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used clinical data linked with administrative health data from Alberta, Canada between April 2008 and March 2021. Three methods were used to define exposure to glyburide and gliclazide in the year before catheterization. Multivariable logistic regression was used to compare the likelihood of a composite outcome of 1\u2010year mortality or rehospitalization with use of glyburide versus use of gliclazide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 11\u2009140 individuals with type 2 diabetes had a cardiac catheterization for acute coronary syndrome. Their mean age was 66\u2009years and 31% were female. In the year before catheterization, 5% used glyburide and 19% used gliclazide. Any glyburide or gliclazide exposure in the year before catheterization was associated with a similar likelihood of all\u2010cause mortality or rehospitalization (adjusted odds ratio [aOR] 1.14, 95% confidence interval [CI] 0.93\u20131.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.20). However, current glyburide exposure (aOR 1.37, 95% CI 1.06\u20131.79;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) and long exposure to glyburide (aOR 1.37, 95% CI 1.03\u20131.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) were associated with a higher likelihood of the composite outcome compared to current and long exposure to gliclazide, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current and long exposure to glyburide was associated with a greater likelihood of mortality or rehospitalization following cardiac catheterization for acute coronary syndrome, when compared to similar gliclazide exposure definitions. This study adds further evidence of the need to avoid using glyburide if a sulphonylurea is required for type 2 diabetes management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15917","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T06:55:43Z","timestamp":1725864943000},"page":"5408-5419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glyburide use is associated with a greater likelihood of mortality or rehospitalization after acute coronary syndrome compared to gliclazide use in adults with type 2 diabetes: A cohort study"],"prefix":"10.1111","volume":"26","author":[{"given":"Wentong","family":"Long","sequence":"first","affiliation":[{"name":"Alberta Diabetes Institute University of Alberta, 1\u2010005 Li Ka Shing Centre for Health Research Innovation  Edmonton Alberta Canada"},{"name":"Department of Pharmacology, Faculty of Medicine and Dentistry, College of Health Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E.","family":"Light","sequence":"additional","affiliation":[{"name":"Alberta Diabetes Institute University of Alberta, 1\u2010005 Li Ka Shing Centre for Health Research Innovation  Edmonton Alberta Canada"},{"name":"Department of Pharmacology, Faculty of Medicine and Dentistry, College of Health Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9880-2129","authenticated-orcid":false,"given":"Scot H.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Alberta Diabetes Institute University of Alberta, 1\u2010005 Li Ka Shing Centre for Health Research Innovation  Edmonton Alberta Canada"},{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2020.08.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2013.04.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1414"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13687"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2424"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-1223"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12456"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.13772"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.2.223"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.4.1845"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00016-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1242"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.06.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00516.2006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.05.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01496.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70213-X"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12173"},{"key":"e_1_2_9_20_1","first-page":"1225","article-title":"Overview of the Alberta provincial project for outcome assessment in coronary heart disease. 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