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Current methods for ketone measurement by people with diabetes include capillary blood or urine testing. These approaches have limitations, including the need to carry testing strips that have a limited shelf life and a requirement for the user to initiate a test. Recent studies have shown the feasibility of continuous ketone monitoring (CKM) via interstitial fluid with a sensor inserted subcutaneously employing an enzymatic electrochemical reaction. Ketone readings can be updated every 5 minutes. In the future, one would expect that commercialized devices will incorporate alarms linked with standardized thresholds and trend arrows. Ideally, to minimize the burden on users, CKM functionality should be integrated with other devices used to implement glucose management, including continuous glucose monitors and insulin pumps. We suggest CKM provision to all at risk of DKA and recommend that the devices should be worn continuously. Those who may particularly benefit are individuals who have T1D, are pregnant, on medications such as sodium\u2010glucose linked transporter (SGLT) inhibitors that increase DKA, people with recurrent DKA, those with T1D undertaking high intensity exercise, are socially or geographically isolated, or those on low carbohydrate diets. The provision of ketone profiles will provide important clinical insights that have previously been unavailable to people living with diabetes and their healthcare professionals.<\/jats:p>","DOI":"10.1111\/dom.15921","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T04:25:51Z","timestamp":1727151951000},"page":"47-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Continuous ketone monitoring: Exciting implications for clinical practice"],"prefix":"10.1111","volume":"26","author":[{"given":"Yee Wen","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-4946","authenticated-orcid":false,"given":"Dale","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Diabetes and Endocrinology St. Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Diabetes and Endocrinology St. Vincent's Hospital  Fitzroy Victoria Australia"},{"name":"Werribee Mercy Hospital  Werribee Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia J.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Diabetes and Endocrinology St. Vincent's Hospital  Fitzroy Victoria Australia"},{"name":"Australian Centre for Accelerating Diabetes Innovations  Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-4032","authenticated-orcid":false,"given":"David N.","family":"O'Neal","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Diabetes and Endocrinology St. Vincent's Hospital  Fitzroy Victoria Australia"},{"name":"Werribee Mercy Hospital  Werribee Victoria Australia"},{"name":"Australian Centre for Accelerating Diabetes Innovations  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2011.03246.x"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i5.514"},{"key":"e_1_2_17_4_1","first-page":"1","article-title":"Metabolic and clinical significance of ketosis","volume":"4","author":"Schade DS","year":"1982","journal-title":"Spec Top Endocrinol Metab"},{"key":"e_1_2_17_5_1","volume-title":"Endotext","author":"Gosmanov AR","year":"2018"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6712a3"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20101258"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010015\u20101171\u20107"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj\u20102020\u2010138513"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010015\u20100709\u20102"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2021.09.007"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.12.011"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010022\u201005787\u20102"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00106"},{"issue":"1","key":"e_1_2_17_15_1","first-page":"18","article-title":"Predictors of five days mortality in diabetic ketoacidosis patients: a prospective cohort study","volume":"46","author":"Suwarto S","year":"2014","journal-title":"Acta Med Indones"},{"key":"e_1_2_17_16_1","volume-title":"Clinical Methods: the History, Physical, and Laboratory Examinations","author":"Comstock JP","year":"1990"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500130048017"},{"key":"e_1_2_17_18_1","unstructured":"The National Diabetes Services Scheme.Ketoacidosis. 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