{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:01:26Z","timestamp":1791525686844,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204063"],"award-info":[{"award-number":["82204063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373589"],"award-info":[{"award-number":["82373589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202311020"],"award-info":[{"award-number":["SZSM202311020"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to investigate the mediating role of inflammatory biomarkers in the causal effect of body composition on glycaemic traits and type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study and a Mendelian randomization (MR) study were used. Observational analyses were performed using data from 4717 Chinese children and adolescents aged 6\u201318\u2009years who underwent dual\u2010energy X\u2010ray absorptiometry for body composition. MR analyses were based on summary statistics from UK Biobank, deCODE2021, Meta\u2010Analysis of Glucose and Insulin\u2010Related Traits Consortium (MAGIC) and other large consortiums. Inflammatory biomarkers included leptin, adiponectin, osteocalcin, fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a retrospective observational study, increased fat mass had a positive effect on homeostasis model assessment of insulin resistance (HOMA\u2010IR) and homeostasis model assessment of pancreatic beta cell function (HOMA\u2010\u03b2) through FGF23, whereas fat\u2010free mass produced the opposite effects. PTH and osteocalcin played significant roles in the association of fat mass and fat\u2010free mass with fasting glucose, fasting insulin and HOMA\u2010IR (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Mediation MR results indicated that childhood body mass index affected glycaemic traits through leptin and adiponectin. There existed a causal effect of fat\u2010free mass on type 2 diabetes via FGF23 (indirect effect: OR [odds ratio]: 1.14 [95% CI, confidence interval: 1.01\u20131.28]) and adiponectin (OR: 0.85 [95% CI: 0.77\u20130.93]). Leptin mediated the causal association of fat mass (indirect effect: \u03b2: \u22120.05 [95% CI: \u22120.07, \u22120.02]) and fat\u2010free mass (\u03b2: 0.03 [95% CI: 0.01, 0.04]) with fasting glucose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that different body compositions have differential influences on glycaemic traits and type 2 diabetes through distinct inflammatory biomarkers. The findings may be helpful in tailoring management of body composition based on inflammatory biomarkers with different glycaemic statuses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15923","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:21:52Z","timestamp":1725420112000},"page":"5444-5454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mediating role of inflammatory biomarkers in the causal effect of body composition on glycaemic traits and type 2 diabetes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-6379","authenticated-orcid":false,"given":"Liwan","family":"Fu","sequence":"first","affiliation":[{"name":"Center for Non\u2010Communicable Disease Management, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Child and Adolescent Chronic Disease Prevention and Control Department Shenzhen Center for Chronic Disease Control  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Center for Non\u2010Communicable Disease Management, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Li","sequence":"additional","affiliation":[{"name":"Child and Adolescent Chronic Disease Prevention and Control Department Shenzhen Center for Chronic Disease Control  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Child and Adolescent Chronic Disease Prevention and Control Department Shenzhen Center for Chronic Disease Control  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-8447","authenticated-orcid":false,"given":"Jie","family":"Mi","sequence":"additional","affiliation":[{"name":"Center for Non\u2010Communicable Disease Management, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"},{"name":"Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.319023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.066"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u201041024\u201003095\u201041593"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0433-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4196-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00898-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88880"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155577"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00599-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2020.02.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.08.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12361"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22426"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a038984"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr525"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2383"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13091541"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322000"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010160"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.811751"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.2.547"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0131"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00847-5"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.04.027"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.02.009"},{"key":"e_1_2_10_27_1","first-page":"40","article-title":"Role of signaling pathways in age\u2010related orthopedic diseases: focus on the fibroblast growth factor family","volume":"11","author":"Li HZ","year":"2024","journal-title":"Mil Med Res"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00675-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02053"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12399-9"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-024-02418-8"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711119105"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-018-0189-3"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13895"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1015046"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2023.102883"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1037546"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1048122"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19366-9"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:04:15Z","timestamp":1761861855000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/dom.15923"],"URL":"https:\/\/doi.org\/10.1111\/dom.15923","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15923\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15923\/v2\/response1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"2024-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}