{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:32:04Z","timestamp":1791941524642,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the mechanisms through which diosgenin inhibits the pathogenesis of non\u2010alcoholic fatty liver disease, focusing particularly on ferroptosis\u2010related pathways and its reliance on\n                      <jats:italic>nuclear factor erythroid 2\u2010related factor 2<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Using a rat model, we showed diosgenin's efficacy in reducing lipid deposition throughout the body and examined its impact on ferroptosis\u2010related gene expression\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Moreover,\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiments using human hepatocellular liver carcinoma cell line cells were conducted to assess oxidative stress and ferroptosis levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diosgenin decreased lipid accumulation and steatosis; lowered serum levels of total cholesterol, triglycerides, low\u2010density lipoprotein cholesterol, glutamic pyruvic transaminase and glutamic oxaloacetic transaminase; reduced interleukin\u20101\u03b2 and tumour necrosis factor\u2010\u03b1; diosgenin decreased malondialdehyde levels; and increased serum superoxide dismutase levels in a rat model of high\u2010fat diet\u2010induced non\u2010alcoholic fatty liver disease. Diosgenin upregulated the expression of\n                      <jats:italic>nuclear factor erythroid 2\u2010related factor 2<\/jats:italic>\n                      and its downstream ferroptosis\u2010related genes to inhibit ferroptosis in the livers of rats with non\u2010alcoholic fatty liver disease. Diosgenin decreased reactive oxygen species levels and enhanced the expression of ferroptosis\u2010related genes in human hepatocellular liver carcinoma cells induced by free fatty acids, with its effects being dependent on\n                      <jats:italic>nuclear factor erythroid 2\u2010related factor 2<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study highlights the potential of diosgenin from Dioscoreaceae plants in mitigating oxidative stress and ferroptosis levels through\n                      <jats:italic>nuclear factor erythroid 2\u2010related factor 2<\/jats:italic>\n                      regulation, offering novel insights into the treatment of non\u2010alcoholic fatty liver disease and other metabolic disorders through traditional Chinese medicine.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15945","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:46:10Z","timestamp":1727678770000},"page":"5745-5756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diosgenin ameliorating non\u2010alcoholic fatty liver disease via\n                    <scp>\n                      <i>Nrf2<\/i>\n                    <\/scp>\n                    \u2010mediated regulation of oxidative stress and ferroptosis"],"prefix":"10.1111","volume":"26","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of The First Clinical Medical College Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of The First Clinical Medical College 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