{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:31Z","timestamp":1772160151299,"version":"3.50.1"},"reference-count":86,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Many patients with type 1 diabetes mellitus (T1DM) met the histological criteria for non\u2010alcoholic steatohepatitis (NASH), which leads to cardiovascular disease morbidity and mortality. Matrix metalloproteinase\u201014 (MMP\u201014) is involved in cardiovascular disease and atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the impact of oral dipeptidyl peptidase\u20104 inhibitor, vildagliptin, as adjunctive therapy on NASH in adolescents with T1DM and its effect on glycaemic control, MMP\u201014 levels and carotid intima media thickness (CIMT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty adolescents with T1DM and NASH were randomly assigned to receive oral vildagliptin (50\u2009mg once daily) for 6\u2009months or not. Glycated haemoglobin, lipid profile, hepatic steatosis index, triglyceride glucose (TyG) index and MMP\u201014 levels were assessed. Transient elastography with controlled attenuation parameter (CAP) was performed together with measuring CIMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      By transient elastography, 12 (20%) patients with T1DM with NASH had elevated liver stiffness \u22657\u2009kPa (F2 stage or higher). Baseline MMP\u201014 was positively correlated to insulin dose (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), triglycerides and TyG index, CIMT, liver stiffness and CAP levels among the studied patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all). After 6\u2009months, patients with T1DM on vildagliptin therapy had significantly lower glycated haemoglobin, lipid profile, hepatic steatosis index and TyG index, as well as MMP\u201014 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). CIMT, liver stiffness and CAP were significantly decreased post\u2010therapy compared with baseline levels and compared with the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Vildagliptin was safe and well\u2010tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Administration of vildagliptin for adolescents with T1DM and NASH improved glycaemic control, dyslipidaemia and MMP\u201014 levels and decreased liver stiffness and CIMT; hence, reducing subclinical atherosclerosis and disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15958","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T09:46:28Z","timestamp":1727257588000},"page":"5857-5869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of vildagliptin as an add\u2010on therapy on matrix metalloproteinase\u201014 levels, liver stiffness and subclinical atherosclerosis in adolescents with type 1 diabetes and 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