{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:31Z","timestamp":1772160151363,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between childhood overweight or obesity and gestational diabetes mellitus (GDM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were sourced from the Genome\u2010Wide Association Studies database on childhood body mass index (BMI), with 39\u2009620 samples and 8\u2009173\u2009382 single\u2010nucleotide polymorphisms (SNPs), and GDM, with 143\u2009441 samples, including 12\u2009332 GDM cases and 20\u2009149\u2009608 SNPs. Mendelian randomization (MR) was conducted, including inverse variance weighting (IVW), MR\u2010Egger regression, and the weighted median method. Statistical heterogeneity among SNPs was assessed using Cochran's Q test. MR\u2010Egger's intercept, the MR\u2010Pleiotropy RESidual Sum and Outlier (PRESSO) test, and funnel plots were used to evaluate pleiotropy. The leave\u2010one\u2010out method tested the robustness of the IVW results by excluding individual SNPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen SNPs highly related to childhood BMI were identified. IVW analysis indicated that higher childhood BMI is a significant risk factor for GDM (odds ratio\u20091.50 [95% confidence interval 1.20\u20131.87];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The direction of the\n                      <jats:italic>\u03b2<\/jats:italic>\n                      value derived from the weighted median method analysis was consistent with that from the IVW analysis. Cochran's Q test showed statistical heterogeneity among SNPs highly related to childhood BMI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), thus prioritizing IVW analysis results. The MR\u2010Egger regression intercept, MR\u2010PRESSO test, and funnel plot analyses demonstrated no horizontal pleiotropy among SNPs highly related to childhood BMI. The leave\u2010one\u2010out analysis indicated that the MR analysis results were largely unchanged after the exclusion of individual SNPs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated childhood BMI is associated with an increased risk of developing GDM, underscoring the need to address childhood obesity as a preventive strategy. Effective interventions to reduce childhood obesity could be crucial in mitigating this risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15975","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:48:44Z","timestamp":1727678924000},"page":"6016-6022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mendelian randomization analysis of the association between childhood overweight or obesity and gestational diabetes mellitus"],"prefix":"10.1111","volume":"26","author":[{"given":"Huaiyan","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Microelectronics Tianjin University  Tianjin City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1561-9327","authenticated-orcid":false,"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.58245"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.190836"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010022\u201004874\u2010x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.640004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.18.5.611"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010023\u201002169\u2010x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.1997.tb01922.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.2.s8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2023.10.133"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.691033"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(02)09678\u20102"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(02)09678\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4759"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15214523"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.19813\/j.cnki.weishengyanjiu.2022.04.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803527"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003442"},{"issue":"5","key":"e_1_2_9_19_1","first-page":"341","article-title":"The effects of independent and combined factors of advanced age, pre\u2010pregnancy BMI, weight gain during early pregnancy, first degree family history of diabetes on the incidence of gestational diabetes","volume":"30","author":"Decui C","year":"2021","journal-title":"Prog Obstet Gynecol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3034"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100099\u20107"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100255\u2010x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20220154"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.922922"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216897"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.11.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.35.9.979"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.5.1069"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1993.tb18835.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.12.2919"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000034509.14906.ae"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1375\/1369052012632"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264406"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12334"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703860"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(21)00314\u20104"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010020\u201000341\u20109"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.4115"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108564"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad088"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3599"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:59:27Z","timestamp":1761886767000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/dom.15975"],"URL":"https:\/\/doi.org\/10.1111\/dom.15975","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15975\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15975\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15975\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15975\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15975\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15975\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15975\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15975\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"2024-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}