{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:06:43Z","timestamp":1777698403431,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PCEGP3_186978"],"award-info":[{"award-number":["PCEGP3_186978"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Roux\u2010en\u2010Y gastric bypass (RYGB) surgery alters postprandial glucose profiles, causing post\u2010bariatric hypoglycaemia (PBH) in some individuals. Due to the liver's central role in glucose homeostasis, hepatic glucose handling might differ in RYGB\u2010operated patients with PBH compared to non\u2010operated healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled RYGB\u2010operated adults with PBH and HCs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910 each). Participants ingested 60\u2009g of [6,6\u2032\u2010\n                      <jats:sup>2<\/jats:sup>\n                      H\n                      <jats:sub>2<\/jats:sub>\n                      ]\u2010glucose (\n                      <jats:sc>d<\/jats:sc>\n                      \u2010glucose) after an overnight fast. Deuterium metabolic imaging (DMI) with interleaved\n                      <jats:sup>13<\/jats:sup>\n                      C magnetic resonance spectroscopy was performed before and until 150\u2009min post\u2010\n                      <jats:sc>d<\/jats:sc>\n                      \u2010glucose intake, with frequent blood sampling to quantify glucose enrichment and gluco\u2010regulatory hormones until 180\u2009min. Glucose fluxes were assessed by mathematical modelling. Outcome trajectories were described using generalized additive models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In RYGB subjects, the hepatic\n                      <jats:sc>d<\/jats:sc>\n                      \u2010glucose signal increased early, followed by a decrease, whereas HCs exhibited a gradual increase and consecutive stabilization. Postprandial hepatic glycogen accumulation and the suppression of endogenous glucose production were lower in RYGB patients than in HCs, despite higher insulin exposure, indicating lower hepatic insulin sensitivity. The systemic rate of ingested\n                      <jats:sc>d<\/jats:sc>\n                      \u2010glucose was faster in RYGB, leading to a higher, earlier plasma glucose peak and increased insulin secretion. Postprandial glucose disposal increased in RYGB patients, without between\u2010group differences in peripheral insulin sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exploiting DMI with stable isotope flux analysis, we observed distinct postprandial hepatic glucose trajectories and parameters of glucose\u2013insulin homeostasis in RYGB patients with PBH versus HCs. Despite altered postprandial glucose kinetics and higher insulin exposure, there was no evidence of impaired hepatic glucose uptake or output predisposing to PBH in RYGB patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16001","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T01:05:31Z","timestamp":1728954331000},"page":"196-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In vivo mapping of postprandial hepatic glucose metabolism using dynamic magnetic resonance spectroscopy combined with stable isotope flux analysis in Roux\u2010en\u2010Y gastric bypass adults and non\u2010operated controls: A case\u2013control study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-3187","authenticated-orcid":false,"given":"Simone","family":"Poli","sequence":"first","affiliation":[{"name":"Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology University of Bern  Bern Switzerland"},{"name":"Translational Imaging Center, Sitem\u2010Insel  Bern Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-4949","authenticated-orcid":false,"given":"Naomi F.","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Graduate School for Health Sciences University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8067-0417","authenticated-orcid":false,"given":"Alessandro","family":"Brunasso","sequence":"additional","affiliation":[{"name":"Department of Information Engineering University of Padova  Padova 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