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For both diets, 30% and 35% of the total calories were from fat and carbohydrates, respectively. The dietary intervention lasted 6\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both diets improved body composition to a similar extent, including weight loss (\u22128.05\u2009\u00b1\u20095.12\u2009kg for the HPA diet and \u22127.70\u2009\u00b1\u20095.47\u2009kg for the HPP diet at 6\u2009months) and fat mass, mainly visceral fat. Both diets had a similar beneficial effect on glucose metabolism, including fasting glucose, insulin, homeostasis model assessment of insulin resistance index and glycated haemoglobin. Other biochemical parameters, including lipid profiles, liver enzymes, adipokines and inflammatory biomarkers, similarly improved in both groups. Fasting incretins, mainly glucagon\u2010like peptide 1, decreased significantly in both groups, and this effect correlated with weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low\u2010calorie HP diets improved body composition, glucose metabolism and other cardiometabolic outcomes, regardless of protein source (either animal or plant sources), in outpatients with prediabetes or T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      The clinical trial was registered in ClinicalTrials.gov (identifier: NCT05456347)\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05456347?term=NCT05456347&amp;rank=1\">https:\/\/clinicaltrials.gov\/study\/NCT05456347?term=NCT05456347&amp;rank=1<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16013","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:53:45Z","timestamp":1729212825000},"page":"268-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Low\u2010calorie, high\u2010protein diets, regardless of protein source, improve glucose metabolism and cardiometabolic profiles in subjects with prediabetes or type 2 diabetes and overweight or obesity"],"prefix":"10.1111","volume":"27","author":[{"given":"Carmen","family":"Rodrigo\u2010Carb\u00f3","sequence":"first","affiliation":[{"name":"Miguel Servet University Hospital, Aragon Health Research Institute, CIBERCV  Zaragoza 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