{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:31:00Z","timestamp":1792816260815,"version":"4.5.0"},"reference-count":87,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and obesity increases risk of cardiovascular disease. This cohort study examines the prognostic value of MASLD, across body weight categories, in a secondary preventative acute myocardial infarction (AMI) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with AMI were stratified into four phenotypes\u2014obesity MASLD, non\u2010obesity MASLD, obesity non\u2010MASLD, non\u2010obesity non\u2010MASLD. The primary outcome was all\u2010cause mortality. Cox regression analysis was performed to investigate determinants of long\u2010term all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 5702 patients, majority were in the non\u2010obesity non\u2010MASLD group (66.7%), followed by obesity MASLD (16.1%), non\u2010obesity MASLD (11.2%) and non\u2010obesity MASLD (6.0%). Across the four phenotypes, obesity MASLD had the highest cardiometabolic burden, followed by non\u2010obesity MASLD. Non\u2010obesity MASLD had the highest risk of heart failure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), cardiogenic shock (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and all\u2010cause long\u2010term mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). The non\u2010obesity MASLD (HR 1.400, 95%CI 1.077\u20131.820,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and obesity MASLD phenotypes (HR 1.222, 95%CI 1.005\u20131.485,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) were independently associated with long\u2010term all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Obesity and non\u2010obesity MASLD phenotypes were predictors of all\u2010cause mortality following AMI, with an even larger magnitude of mortality risk in the non\u2010obesity MASLD group. The recognition of MASLD and its body weight phenotypes will be beneficial in the prognostication following AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16062","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T02:25:13Z","timestamp":1731378313000},"page":"683-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010term all\u2010cause mortality of metabolic\u2010dysfunction associated steatotic liver disease based on body weight phenotypes following acute myocardial infarction: A retrospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Jaycie","family":"Koh","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Mohamed","sequence":"additional","affiliation":[{"name":"King Fahd Military Medical Complex  Dhahran Saudi Arabia"},{"name":"Department of Cardiology, National University Heart Centre National University Health System  Singapore Singapore"},{"name":"Cardiology Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwyneth","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Wong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Chen","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickram Vijay","family":"Anand","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Chong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yip Han","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-6082","authenticated-orcid":false,"given":"Jiong\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, National University Heart Centre National University Health System  Singapore Singapore"},{"name":"Department of Surgery, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Nanomedicine Translational Research Programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Meng","family":"Khoo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew Pang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine National University Hospital  Singapore Singapore"},{"name":"Cardiovascular Research Institute, National University Heart Centre National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-4743","authenticated-orcid":false,"given":"Mark","family":"Muthiah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"},{"name":"National University Centre for Organ Transplantation National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios K.","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology ASO\/EASO COM King's College Hospital NHS Foundation Trust  London UK"},{"name":"Obesity, Type 2 Diabetes and Immunometabolism Research Group, Department of Diabetes, Faculty of Cardiovascular Medicine &amp; 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