{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:19Z","timestamp":1787014099267,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["Z230021"],"award-info":[{"award-number":["Z230021"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To provide an updated comprehensive evaluation of the quality and evidence association of existing studies on health outcomes related to intermittent fasting (IF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a systematic search of PubMed, Web of Science, Cochrane Library, and Embase databases, covering literature up to June 2024. Meta\u2010analyses and systematic reviews that include adult populations and quantitatively analyse health outcomes related to IF interventional studies are included. For evidence with complete data, we reanalyzed health evidence effect sizes and 95% confidence intervals using random\u2010effects models. Article quality and the certainty of the evidence were graded using A Measurement Tool to Assess Systematic Reviews (AMSTAR\u20102), Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, and a standardized credibility grading system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve meta\u2010analysis studies and 122 health outcome associations with IF were identified. High\u2010quality evidence indicated significant associations between time\u2010restricted eating (TRE) and weight loss, fat mass reduction, decreased fasting insulin and glycosylated haemoglobin levels in overweight or obese adults, as well as between the 5:2 diet and reduced low\u2010density lipoprotein cholesterol levels. Moderate\u2010to\u2010low\u2010quality evidence suggested associations between modified alternate\u2010day fasting and improvements in body weight, lipid profile and blood pressure. Additionally, high\u2010to\u2010low\u2010quality evidence showed that IF regimens effectively improved liver health in non\u2010alcoholic fatty liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This umbrella review highlights IF, especially TRE, as a promising intervention for weight and metabolic health, particularly beneficial for overweight or obese adults. We also highlight the need for further extensive research to understand the long\u2010term effects, individualized IF plans and potential adverse effects of IF in different populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16092","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:15:10Z","timestamp":1733098510000},"page":"920-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes"],"prefix":"10.1111","volume":"27","author":[{"given":"Zixin","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongge","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-9571","authenticated-orcid":false,"given":"Xingang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010022\u201000638\u2010x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010071816\u2010064634"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00006.2022"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010052020\u2010041327"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665119000636"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.08.021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051192"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102891\u20109\u201057"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22\u20101622"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103408"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234915"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd8034"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.123.010936"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.07.016"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002738"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.39558"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102519"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuac103"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102022\u2010071609"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102023\u2010077310"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.02.037"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.2859"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2035"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2023.10.023"},{"key":"e_1_2_11_30_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5 (Updated August 2024)","author":"Higgins JPT","year":"2024"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.8166"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70267\u20104"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.07.152"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental\u20102018\u2010300014"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.11.007"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2023.11.009"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109000"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2024.102952"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16060876"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.10.009"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scispo.2023.01.005"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3194"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1079250"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1974335"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010023\u201009853\u2010x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes22050"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.586036"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/jnr.0000000000000469"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002287\u20107"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.12.001"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa644"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101161"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15163661"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001176"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad036"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051405"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028662\u20105"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100271\u20108"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665117003962"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010019\u20102007\u2010z"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010006\u20109022\u20100"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.02.003"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.12.006"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000212"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000330"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.04.015"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030532"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008234"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2022.10.001"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937\u2010023\u201000909\u2010x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114833"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522001581"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.4153"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2088687"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2023.106452"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.20220033"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/full-xml\/10.1111\/dom.16092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:53:06Z","timestamp":1775865186000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.16092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/dom.16092"],"URL":"https:\/\/doi.org\/10.1111\/dom.16092","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.16092\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16092\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16092\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16092\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,1]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}