{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:41:52Z","timestamp":1790001712816,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of this study was to examine the effects of empagliflozin on endothelium\u2010dependent and endothelium\u2010independent vasodilatation and systemic hemodynamic parameters and to assess the role of the nitric oxide (NO) system in patients with type 2 diabetes (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this double\u2010blind, placebo\u2010controlled cross over trial, patients with T2DM were treated with either empagliflozin 10\u2009mg or matching placebo for 4\u2009weeks. Following a 2\u2010week washout, participants were crossed over to 4\u2009weeks of the opposite treatment. Forearm blood flow (FBF) was measured after each treatment period using venous occlusion plethysmography. Acetylcholine and sodium nitroprusside (SNP) were infused into the brachial artery to assess endothelium\u2010dependent and endothelium\u2010independent vasodilatory function, respectively. Total peripheral resistance, 24\u2010h blood pressure (BP) and biochemical markers of NO activity were measured as well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen participants completed the trial. The mean age was 68\u2009\u00b1\u20098\u2009years, and 69% were male. The SNP response increased by 21% (geometric mean ratio 1.21, 95% CI: 1.09; 1.33) during treatment with empagliflozin compared to placebo (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001), but not during acetylcholine infusion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.290). Empagliflozin decreased 24\u2010h systolic BP by 5\u2009mmHg (95% CI: \u22129; \u22121\u2009mmHg) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), diastolic BP by 2\u2009mmHg (95% CI: \u22125; 0\u2009mmHg) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029) and systemic vascular resistance by 48 dyn\u00d7s\/m\n                      <jats:sup>5<\/jats:sup>\n                      (95% CI: \u221294; \u22121\u2009dyn\u00d7s\/m\n                      <jats:sup>5<\/jats:sup>\n                      ) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044). Furthermore, empagliflozin reduced plasma levels of nitrite and urinary levels of NOx.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Empagliflozin improves endothelium\u2010independent vasodilation, reduces vascular resistance and lowers 24\u2010h BP in patients with T2DM, whereas no change in endothelial\u2010dependent vasodilation was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      EU Clinical Trials Register number: 2019\u2010004303\u201012 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2019-004303-12\/DK\">https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2019-004303-12\/DK<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16097","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T03:44:48Z","timestamp":1732851888000},"page":"1123-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>SGLT2<\/scp>\n                    inhibition improves endothelium\u2010independent vasodilatory function in type 2 diabetes: A double\u2010blind, randomized, placebo\u2010controlled crossover trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5907-9796","authenticated-orcid":false,"given":"Didde 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