{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:22:42Z","timestamp":1785435762484,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate and compare the plasma glucose (PG) response during spontaneous fasted morning moderate\u2010intensity exercise with and without injection of subcutaneous glucagon in adults with type 1 diabetes (T1D) treated with an automated insulin delivery (AID) system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten adults (four female) with T1D (age 50 [42\u201367] years, diabetes duration: 22 [14\u201344] years, HbA1c: 55 [47\u201369] mmol\/mol) treated with the MiniMed\u2122 780G AID system participated in a proof\u2010of\u2010concept two\u2010period, crossover trial. Fasting participants undertook a 45\u2009min bout of continuous moderate\u2010intensity (~60% V\u0307O\n                      <jats:sub>2peak<\/jats:sub>\n                      ) exercise on a cycle ergometer followed by 1\u2009h of rest. Before exercise, 150\u2010\u03bcg glucagon was administered subcutaneously on visit 1 (GLUC) but not on visit 2 (NO\u2010GLUC). Temporary target on the AID was activated 15\u2009min before until 15\u2009min after exercise cessation. Blood samples were taken at 5\u2010 and 15\u2010min intervals for measuring PG and biomarkers. Data were analysed using paired\n                      <jats:italic>t<\/jats:italic>\n                      tests or repeated measures ANOVA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Time in range (3.9\u201310.0\u2009mmol\/L) was 100% on both study visits. No hypoglycaemia (&lt;3.9\u2009mmol\/L) occurred in either arm. The GLUC arm had significantly higher mean PG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), area under the PG curve (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), coefficient of variation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), peak PG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and PG at the end of exercise (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). No differences in endogenous glucoregulatory hormones were observed between visits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adults with T1D treated with the MiniMed\u2122 780G can perform spontaneous fasted moderate\u2010intensity exercise without hypoglycaemia. Therefore, glucagon was not needed for prevention of hypoglycaemia in such situations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16103","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T22:55:51Z","timestamp":1732748151000},"page":"1164-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is low\u2010dose glucagon needed and effective in preventing fasted exercise\u2010induced hypoglycaemia in type 1 diabetes treated with the\n                    <scp>MiniMed 780G<\/scp>\n                    , an automated insulin delivery system?"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4343-7777","authenticated-orcid":false,"given":"Sissel Banner","family":"Lundemose","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Copenhagen Clinical and Translational Research, Diabetes Technology Research  Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen Clinical and Translational Research, Diabetes Technology Research  Herlev Denmark"},{"name":"Applied Sport, Technology, Exercise and Medicine Research Centre Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete Bechmann","family":"Christensen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen Clinical and Translational Research, Diabetes Technology Research  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-9457","authenticated-orcid":false,"given":"Christian","family":"Laugesen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen Clinical and Translational Research, Diabetes Technology Research  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-6449","authenticated-orcid":false,"given":"Richard M.","family":"Bracken","sequence":"additional","affiliation":[{"name":"Applied Sport, Technology, Exercise and Medicine Research Centre Swansea University  Swansea UK"},{"name":"Health Technology and Solutions Interdisciplinary Research Institute, Faculty of Science and Engineering Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens Juul","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-6071","authenticated-orcid":false,"given":"Ajenthen Gayathri","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen Clinical and Translational Research, Diabetes Technology Research  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen Clinical and Translational Research, Diabetes Technology Research  Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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