{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:55:18Z","timestamp":1780988118615,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the efficacy and safety of a combination of phentermine and delayed\u2010release topiramate (PHEN\/TPM CR) versus placebo as an adjunct to standard lifestyle recommendations in Korean adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This 56\u2010week, randomized, double\u2010blind, placebo\u2010controlled, phase 4 trial enrolled adults (age 19\u201370\u2009years) with obesity (BMI\u2009\u2265\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) at eight sites in South Korea. After a 12\u2010week lifestyle programme, participants were randomly assigned in a 1:1 ratio to receive PHEN\/TPM CR or placebo. PHEN\/TPM CR was commenced at 3.75\u2009mg\/23\u2009mg daily for 14\u2009days and increased to 7.5\u2009mg\/46\u2009mg daily, and to 15\u2009mg\/92\u2009mg if 3% weight loss was not achieved after 12\u2009weeks. The primary outcomes were percentage change in body weight from baseline to Week 56.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 232 participants underwent randomization. At 56\u2009weeks, the percentage change in body weight was \u22128.3% with PHEN\/TPM CR and \u22122.3% with placebo (treatment difference \u22126.1%; 95% confidence interval [CI], \u22127.7 to \u22124.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Participants receiving PHEN\/TPM CR were more likely to achieve \u22655% weight loss compared with those receiving placebo (68.5% vs. 25.0%, odds ratio [OR], 6.4; 95% CI, 3.5 to 11.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Dizziness, paraesthesia and dry mouth were more common in the PHEN\/TPM CR group, although most adverse events were mild or moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Administration of PHEN\/TPM CR plus lifestyle intervention in Korean adults with obesity resulted in a greater reduction in body weight and adiposity than lifestyle intervention alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16119","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T03:11:39Z","timestamp":1734664299000},"page":"1242-1250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the efficacy and safety of controlled\u2010release phentermine\/topiramate in adults with obesity in Korea: A randomized, double\u2010blind, placebo\u2010controlled, phase 4 trial (\n                    <scp>QUEEN<\/scp>\n                    's study)"],"prefix":"10.1111","volume":"27","author":[{"given":"Sangmo","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Guri Hospital Hanyang University, College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gangneung Asan Hospital University of Ulsan College of Medicine  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-4675","authenticated-orcid":false,"given":"Eun Seok","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Kyung","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Kyung Hee University Hospital at Gangdong  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sejong General Hospital  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gachon University Gil Hospital  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-8412","authenticated-orcid":false,"given":"Sungrae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Joon","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-834X","authenticated-orcid":false,"given":"Chang Beom","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Guri Hospital Hanyang University, College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362191"},{"key":"e_1_2_11_3_1","first-page":"497","volume-title":"Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors","author":"James WPT","year":"2004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23031"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23016"},{"key":"e_1_2_11_6_1","first-page":"131","article-title":"Clinical utility of phentermine\/topiramate (Qsymia) combination for the treatment of obesity","volume":"6","author":"Shin JH","year":"2013","journal-title":"Diabetes, Metabolic Syndrome and Obesity"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60205-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.330"},{"key":"e_1_2_11_9_1","unstructured":"VIVUS LLC.QSYMIA (phentermine and topiramate extended\u2010release capsules) [package insert].2012. 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