{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:05:00Z","timestamp":1782925500641,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate glycaemic control in Chinese adults with type 2 diabetes (T2D) initiating, or switching to insulin degludec\/insulin aspart (IDegAsp), a co\u2010formulation of basal, and bolus insulin, in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A 20\u2010week, prospective, single\u2010arm, open\u2010label, non\u2010interventional study was conducted in Chinese adults with T2D initiating, or switching to IDegAsp after anti\u2010hyperglycaemic treatment with oral antidiabetic drugs (OADs), other insulins, or glucagon\u2010like peptide\u20101 receptor agonists. The primary endpoint was a change in HbA\n                      <jats:sub>1c<\/jats:sub>\n                      from baseline to end of the study; the secondary endpoints included a change in fasting plasma glucose and Diabetes Treatment Satisfaction Questionnaire (DTSQ) score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant reductions were observed in mean HbA\n                      <jats:sub>1c<\/jats:sub>\n                      and fasting plasma glucose, among both the overall population (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009878; \u22121.27%\u2010points [95% CI: \u22121.36; \u22121.19];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001, and \u22121.61\u2009mmol\/L [95% CI: \u22121.81; \u22121.41];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001, respectively), and in subgroups switching from OADs only, or basal, or premix insulins \u00b1 OADs. The mean total DTSQ score increased from 26.4 (baseline) to 31.6 (end\u2010of\u2010study). No significant, or unexpected tolerability, or safety issues were observed. Significant reductions were observed in incidence rates of non\u2010severe (rate ratio 0.37 [95% CI: 0.24; 0.59];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and nocturnal non\u2010severe (rate ratio 0.45 [95% CI: 0.21; 0.94];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0326) hypoglycaemic episodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a broad, real\u2010world Chinese population of adults with T2D, initiating or switching to IDegAsp was associated with improved glycaemic control and lower rates of hypoglycaemia. The use of IDegAsp could be an effective treatment option for those with suboptimal glycaemic control or therapeutic inertia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16139","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T03:01:47Z","timestamp":1734663707000},"page":"1388-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Improved glycaemic control in people with type 2 diabetes initiating or switching to\n                    <scp>IDegAsp<\/scp>\n                    in a real\u2010world setting in China"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-1798","authenticated-orcid":false,"given":"Lixin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Endocrinology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-2340","authenticated-orcid":false,"given":"Liming","family":"Chen","sequence":"additional","affiliation":[{"name":"Chu Hsien\u2010I Memorial Hospital &amp; Tianjin Institute of Endocrinology Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhao","sequence":"additional","affiliation":[{"name":"The People's Hospital of Jiangmen  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Chifeng  Chifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcheng","family":"Ding","sequence":"additional","affiliation":[{"name":"Hubei University of Medicine  Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrinology Department Jiangning Hospital affiliated to Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Novo Nordisk (Shanghai) Pharma Trading Co. 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