{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:40:13Z","timestamp":1791567613997,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Women with previous gestational diabetes mellitus (GDM) have an increased risk for later development of type 2 diabetes. During pregnancy, GDM affects the cardio\u2010metabolic protein profile; however, it is unknown how GDM affects the cardio\u2010metabolic protein profile in the long term and if it is associated with type 2 diabetes after GDM. We hypothesise that the cardio\u2010metabolic protein profile is affected long term and is associated with the development of type 2 diabetes after GDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A case\u2013control follow\u2010up study based on the Odense GDM Follow\u2010Up Study (OGFUS) cohort, which included women with previous GDM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009128) and matched controls without previous GDM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970). Blood samples from a follow\u2010up assessment 8\u201310\u2009years after delivery were analysed using a 29\u2010plex panel of apolipoproteins, transport and inflammation\/immune proteins using multiple\u2010reaction\u2010monitoring mass spectrometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Apolipoprotein A\u2010I, D and M were significantly lower in women with previous GDM compared to controls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while apolipoprotein L\u2010I, H, vitamin D binding protein, CRP, vitronectin, transthyretin and complement factors 3 and B were significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005, respectively). All associations remained significant after adjustment for multiple testing except CRP, whereas apolipoprotein D, vitronectin and complement factors 3 and B were associated with the development of type 2 diabetes in women with previous GDM (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The cardio\u2010metabolic protein profile 8\u201310\u2009years after pregnancy is altered in women with previous GDM. Apolipoprotein D, vitronectin and complement factors 3 and B are candidate risk markers of type 2 diabetes after GDM pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16148","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:21:23Z","timestamp":1735863683000},"page":"1456-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The cardio\u2010metabolic protein profile is associated with development of type 2 diabetes at long term follow\u2010up after gestational diabetes mellitus: Results from the\n                    <scp>OGFUS<\/scp>\n                    study"],"prefix":"10.1111","volume":"27","author":[{"given":"Simone J.","family":"Hallig","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jori","family":"Aalders","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria H.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense Denmark"},{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Vinter","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense Denmark"},{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidelma","family":"Dunne","sequence":"additional","affiliation":[{"name":"Diabetes Clinical Trials Network and Institute for Clinical Trials University of Galway, Galway University Hospital  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-4224","authenticated-orcid":false,"given":"Kurt","family":"H\u00f8jlund","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno 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