{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:50:08Z","timestamp":1792227008394,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effectiveness of imeglimin in improving liver function and fibrosis in patients with type 2 diabetes (T2D) complicated by metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a multicentre study involving 80 patients with T2D and MASLD who were treated with or without imeglimin for 24\u2009weeks. We assessed the changes in diabetes\u2010related parameters, including HbA1c, fasting blood glucose, glycoalbumin and C\u2010peptide index. Liver function was monitored using AST, ALT, \u03b3\u2010GTP and liver fibrosis indicators such as Fib\u20104 index and FibroScan\u2010AST (FAST) score. Liver fat content and stiffness were measured using controlled attenuation parameter and vibration\u2010controlled transient elastography, which were measured using FibroScan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the control group, imeglimin treatment led to a significant reduction in HbA1c levels, fasting blood glucose and liver\u2010related parameters, including AST, ALT and \u03b3\u2010GTP. Additionally, the Fib\u20104 index and FAST score, which reflect liver fibrosis and inflammation, were significantly lower in the imeglimin group. Liver fat content and stiffness remained unchanged during the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Imeglimin efficaciously improved liver inflammation and fibrosis in patients with T2D and MASLD, with no significant changes in liver fat content or stiffness. These findings suggest that imeglimin is a promising therapeutic drug for the management of MASLD in the context of T2D, warranting further research on its long\u2010term efficacy and mechanisms of action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16157","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T01:18:36Z","timestamp":1735262316000},"page":"1498-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of imeglimin in patients with type 2 diabetes mellitus complicated by metabolic dysfunction\u2010associated steatotic liver disease: A multicentre study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-5263","authenticated-orcid":false,"given":"Kensaku","family":"Fukunaga","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine Kagawa University  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