{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:56:18Z","timestamp":1790470578342,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>There is ongoing debate concerning the association of metformin with the risk of dementia in type 2 diabetes mellitus (T2DM). This study was conducted to evaluate the impact of metformin therapy on dementia in patients with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Embase, Cochrane Library, Web of Science and the\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      website were searched until 9 April 2024. Cohort studies investigating the effects of metformin therapy compared with other antidiabetic drugs or no therapy in T2DM were included. The hazard ratio (HR) and the 95% confidence interval (CI) were computed using the random effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty cohort studies (24 individual comparisons) involving 3\u2009463\u2009100 participants were identified. A meta\u2010analysis revealed that people with T2DM who take metformin are linked to a lower incidence of all\u2010cause dementia compared to non\u2010user (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917, HR\u2009=\u20090.76, 95% CI\u2009=\u20090.65\u20130.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200998.9%) and sulfonylureas (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095, HR\u2009=\u20090.88, 95% CI\u2009=\u20090.85\u20130.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20099.7%), but not to thiazolidinedione (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092, HR\u2009=\u20090.53, 95% CI\u2009=\u20090.08\u20133.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.503,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200992.7%). Additionally, metformin showed favourable effects in non\u2010specified T2DM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919, HR\u2009=\u20090.75, 95% CI\u2009=\u20090.64\u20130.89), but not in newly diagnosed T2DM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095, HR\u2009=\u20091.01, 95% CI\u2009=\u20090.81\u20131.27).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metformin might correlate with a lower dementia incidence in people with T2DM. However, it is crucial to interpret these results with caution considering the high heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16192","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:07Z","timestamp":1736380807000},"page":"1992-2001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of Metformin use with risk of dementia in patients with type 2 diabetes: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7909-376X","authenticated-orcid":false,"given":"Chunbian","family":"Tang","sequence":"first","affiliation":[{"name":"Medical School of Tianjin University  Tianjin China"},{"name":"Department of General Medicine Peking University Binhai Hospital (Tianjin Fifth Central Hospital)  Tianjin 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