{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:59:49Z","timestamp":1792015189828,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the effects of ipragliflozin, a sodium\u2010dependent glucose transporter\u20102 inhibitor, and those of metformin on the visceral fat area (VFA), a prospective, multi\u2010centre, open\u2010label, blinded\u2010endpoint, randomized, controlled study was undertaken. The generated data were used to examine the effects of ipragliflozin and metformin on indices of hepatic steatosis and liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In total, 103 Japanese patients with type\u20102 diabetes (T2D), body mass index (BMI) of \u226522\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and glycated haemoglobin level of 7%\u201310% were randomly administered ipragliflozin 50\u2009mg or metformin 1000\u2009mg for 24\u2009weeks. Various parameters, including hepatic steatosis indices, fatty liver index (FLI), hepatic steatosis index (HSI), non\u2010alcoholic fatty liver disease\u2010liver fat score (NAFLD\u2010LFS), liver fibrosis indices, AST to platelet ratio index (APRI) and fibrosis\u20104 (FIB\u20104) index, were compared in the sub\u2010analyses. The correlations between changes in each index and VFA were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, patients demonstrated moderate hepatic steatosis, with FLI scores of 52.9\u2009\u00b1\u200926.6 and 57.8\u2009\u00b1\u200929.0 in the ipragliflozin and metformin groups, respectively. At 24\u2009weeks, compared with metformin, ipragliflozin showed improvements in hepatic steatosis indices: FLI (\u22129.24\u2009\u00b1\u200910.7 vs. \u22123.45\u2009\u00b1\u200911.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), HSI (\u22121.45\u2009\u00b1\u20092.32 vs. \u22120.45\u2009\u00b1\u20091.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), NAFLD\u2010LFS (\u22120.70\u2009\u00b1\u20091.46 vs. \u22120.04\u2009\u00b1\u20090.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and liver fibrosis index: APRI (\u22120.110\u2009\u00b1\u20090.323 vs. 0.033\u2009\u00b1\u20090.181,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). In the ipragliflozin group, changes in FLI and HSI were correlated with VFA reduction (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.340,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.367,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with metformin, ipragliflozin improved multiple hepatic steatosis and liver fibrosis indices, suggesting that ipragliflozin exerts potential hepatoprotective effects in early\u2010stage liver disease associated with T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16198","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:35:11Z","timestamp":1736814911000},"page":"2059-2069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of the\n                    <scp>SGLT2<\/scp>\n                    inhibitor ipragliflozin and metformin on hepatic steatosis and liver fibrosis: Sub\u2010analysis of a randomized controlled study"],"prefix":"10.1111","volume":"27","author":[{"given":"Kiichi","family":"Hirayama","sequence":"first","affiliation":[{"name":"Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Science Chiba University  Chiba Japan"},{"name":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism Kimitsu Chuo Hospital  Kisarazu Japan"},{"name":"Department of Internal Medicine Minami\u2010Boso City Tomiyama National Health Insurance Hospital  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