{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:36:16Z","timestamp":1792506976435,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019944","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>People with type 2 diabetes (T2D) and glycated haemoglobin (HbA1c) \u22659% may benefit from fixed\u2010ratio combination therapies such as iGlarLixi (insulin glargine 100\u2009U\/mL and lixisenatide 33\u2009\u03bcg\/mL). Use of continuous glucose monitoring (CGM) is recommended, but data are lacking to assess the impact of iGlarLixi in individuals with HbA1c \u22659%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Soli\u2010CGM (NCT05114590) was a 16\u2010week, multicentre, open\u2010label study evaluating the efficacy of once\u2010daily iGlarLixi using blinded CGM\u2010based metrics in insulin\u2010naive adults with HbA1c \u22659%\u201313% who were receiving \u22652 oral antihyperglycaemic agents (OADs)\u2009\u00b1\u2009glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs). The primary outcome was the change from baseline to week 16 in percent time in range (TIR; 70\u2013180\u2009mg\/dL). Secondary outcomes included change in mean daily blood glucose (BG), maximum postprandial glucose 4\u2009h post\u2010breakfast (PPG\u20104\u2009h), and time above range (TAR; &gt;180\u2009mg\/dL). On\u2010treatment hypoglycaemia was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study enrolled 124 participants (mean age, 55.6\u2009years; HbA1c, 10.2%). Sixteen weeks of treatment with iGlarLixi improved TIR (+26.2%), mean BG (\u221252.5\u2009mg\/dL), maximum PPG\u20104\u2009h (\u221273.7\u2009mg\/dL), and TAR (\u221228.7%); all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001. Rates of American Diabetes Association level 1 (BG &lt;70 but \u226554\u2009mg\/dL) and level 2 (BG &lt;54\u2009mg\/dL) hypoglycaemia were reported as 1.4 and 0.6 events per person\u2010year, respectively. No level 3 events (requiring assistance) were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In people with T2D suboptimally controlled on \u22652 OADs\u2009\u00b1\u2009GLP\u20101 RAs, 16\u2009weeks of treatment with iGlarLixi significantly improved TIR and reduced TAR without severe hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16214","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:29:49Z","timestamp":1738715389000},"page":"2173-2182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of\n                    <scp>iGlarLixi<\/scp>\n                    on continuous glucose monitoring\u2014measured time in range in insulin\u2010naive adults with suboptimally controlled type 2 diabetes"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-1255","authenticated-orcid":false,"given":"Juan P.","family":"Fr\u00edas","sequence":"first","affiliation":[{"name":"Biomea Fusion  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-7900","authenticated-orcid":false,"given":"Alexandria","family":"Ratzki\u2010Leewing","sequence":"additional","affiliation":[{"name":"University of Maryland Institute for Health Computing  Bethesda Maryland USA"},{"name":"Division of Gerontology, Department of Epidemiology and Public Health University of Maryland School of Medicine  Baltimore Maryland USA"},{"name":"Department of Epidemiology and Biostatistics Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Dex","sequence":"additional","affiliation":[{"name":"Sanofi  Bridgewater New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Meneghini","sequence":"additional","affiliation":[{"name":"Sanofi  Bridgewater New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Ividata  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viral N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Indiana University Center for Diabetes and Metabolic Diseases Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.3474"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S123389"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13885"},{"key":"e_1_2_9_5_1","unstructured":"U.S. Centers for Disease Control and Prevention.National Diabetes Statistics Report.2024.https:\/\/www.cdc.gov\/diabetes\/php\/data-research\/index.html. 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