{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:36Z","timestamp":1772160156908,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Individuals with liver insulin\u2010resistant (LIR) or muscle insulin\u2010resistant (MIR) phenotypes may respond differently to dietary interventions. Given the interaction between insulin resistance and cardiovascular risk, this sub\u2010analysis of the PERSON study examined whether a personalized diet according to MIR or LIR phenotypes improves vascular function and cardiovascular disease risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We randomized 119 participants to a 12\u2010week low\u2010fat, high\u2010protein, high\u2010fibre diet (LFHP; may be optimal for LIR) or Mediterranean diet (high in monounsaturated fat, HMUFA; may be optimal for MIR). Randomization linked the insulin\u2010resistant (IR) phenotype to the proposed optimal diet, leading to PhenoDiet A (MIR\u2010HMUFA and LIR\u2010LFHP) and PhenoDiet B (MIR\u2010LFHP and LIR\u2010HMUFA). Before and after the intervention, vascular function (carotid artery reactivity) and cardiovascular risk factors (blood pressure, total cholesterol, HDL\u2010cholesterol and Framingham risk score) were examined. A 7\u2010point oral glucose tolerance test was performed to determine insulin resistance (Matsuda index and HOMA\u2010IR) and disposition index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following drop\u2010out (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918), 101 participants finished the intervention (54 women, 61\u2009\u00b1\u20097\u2009years, 27.6 [26.4;30.0] kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), with\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200980 available for the primary outcome of vascular function. Overall, the dietary interventions significantly decreased blood pressure, total cholesterol, HDL\u2010cholesterol and the Framingham risk score (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while vascular function was not affected (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.485). Insulin resistance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001), but not disposition index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.362), was significantly improved after intervention. The Matsuda index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.078) tended to increase more and total cholesterol (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.052) tended to decrease more in PhenoDiet group B than A, but other changes in outcome parameters were not significantly different between PhenoDiet groups. The LFHP diet resulted in more pronounced improvements in cholesterol, diastolic blood pressure (DBP) and insulin resistance compared with the HMUFA diet (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 12\u2010week diet improves metabolic and cardiovascular outcomes, but not vascular function in insulin\u2010resistant adults with overweight or obesity. Whilst the LFHP diet resulted in greater improvements in cardiometabolic risk markers than the HMUFA diet, we found no significant differences between the PhenoDiet groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16261","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:46:32Z","timestamp":1740894392000},"page":"2601-2612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of a 12\u2010week personalized dietary intervention on vascular function and cardiovascular risk factors"],"prefix":"10.1111","volume":"27","author":[{"given":"Lisa","family":"Wanders","sequence":"first","affiliation":[{"name":"Radboud Institute for Health Sciences, Department of Physiology Radboud university medical center  Nijmegen The Netherlands"},{"name":"TiFN  Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk","family":"Gijbels","sequence":"additional","affiliation":[{"name":"TiFN  Wageningen The Netherlands"},{"name":"Division of Human Nutrition and Health Wageningen University  Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabby B.","family":"Hul","sequence":"additional","affiliation":[{"name":"Department of Human Biology Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith J. M.","family":"Feskens","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University  Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia A.","family":"Afman","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University  Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen E.","family":"Blaak","sequence":"additional","affiliation":[{"name":"Department of Human Biology Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T. 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