{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:35:51Z","timestamp":1793223351901,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["2025\u201000052B"],"award-info":[{"award-number":["2025\u201000052B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the putative association between semaglutide and non\u2010arteritic anterior ischaemic optic neuropathy (NAION).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data from national health registries in Denmark (2018\u20132024) and Norway (2018\u20132022) were used to compare NAION risk in individuals with type 2 diabetes initiating semaglutide versus sodium\u2010glucose co\u2010transporter 2 inhibitors (SGLT\u20102is). A supplementary self\u2010controlled analysis examined NAION risk among all semaglutide users. National estimates were pooled using a fixed\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 44\u2009517 users of semaglutide for the management of type 2 diabetes in Denmark and 16\u2009860 in Norway, with a total of 32 NAION events observed. The unadjusted incidence rate of NAION was 2.19\/10\u2009000 person\u2010years among Danish semaglutide initiators, compared to 1.18 among SGLT\u20102i initiators. In Norway, the corresponding rates were 2.90 and 0.92, respectively. After adjustment, the pooled hazard ratio (HR) was 2.81 (95% confidence interval [CI] 1.67\u20134.75), and the incidence rate difference (IRD) was +1.41 (95% CI +0.53 to +2.29) per 10\u2009000 person\u2010years. Estimates were consistent across both countries but higher and less precise in Norway (HR 7.25; 95% CI 2.34\u201322.4) compared to Denmark (HR 2.17; 95% CI 1.20\u20133.92). Results remained consistent across sensitivity and supplementary analyses, with a stronger association observed in a post hoc per\u2010protocol analysis (HR 6.35; 95% CI 2.88\u201314.0). In the supplementary self\u2010controlled study, symmetry ratios (SRs) for NAION were 1.14 (95% CI 0.55\u20132.36) in Denmark and 2.67 (95% CI 0.91\u20138.99) in Norway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of semaglutide for managing type 2 diabetes is associated with an increased risk of NAION compared with the use of SGLT\u20102is. However, the absolute risk remains low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16316","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T01:15:15Z","timestamp":1742260515000},"page":"3094-3103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Use of semaglutide and risk of non\u2010arteritic anterior ischemic optic neuropathy: A Danish\u2013Norwegian cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-0479","authenticated-orcid":false,"given":"Emma","family":"Simonsen","sequence":"first","affiliation":[{"name":"Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8651-6072","authenticated-orcid":false,"given":"Lars 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