{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:33:52Z","timestamp":1791804832465,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The body mass index (BMI), as an easy\u2010to\u2010calculate measure of body fatness, is closely associated with all\u2010cause mortality, but few studies with a large enough scale have examined the relationship between BMI and quality of life. A comprehensive and precise insight into a new range is needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Based on the ChinaHEART (Health Evaluation And risk Reduction through nationwide Teamwork), a nationwide, population\u2010based cohort study, 4,485,773 participants living in 20,159 communities or villages were passively followed for death records, through a linkage of data with the National Mortality Surveillance System and Vital Registration. Firstly, we conducted Cox proportional\u2010hazards regression models to assess the hazard ratios (HRs) of BMI on the risk of all\u2010cause and cause\u2010specific mortality. Secondly, we used logistic regression models to examine associations between BMI and health\u2010related quality of life (HRQL). Fully adjusted models were adjusted for age, sex, annual household income, occupation, education level, marriage, medical insurance, urbanity, tobacco smoking, alcohol consumption and the history of hypertension, diabetes mellitus, dyslipidaemia and cardiovascular disease (CVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 4\u2009485\u2009773 included participants with an average age of 56.4\u2009\u00b1\u200910.0\u2009years, 59.0% were female. During the follow\u2010up period, which had a median duration of 5.3\u2009years, a total of 142\u2009004 cases of all\u2010cause mortality were confirmed. After adjusting for participant characteristics and lifestyles, we observed the U\u2010shaped association between BMI and all\u2010cause mortality with an inflection of 26\u201327\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and the estimated HR per 1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      increase in BMI was 0.92 (95% CI 0.92\u20130.93) and 1.03 (95% CI 1.03\u20131.04) below and above the turning point, respectively. An inverted J\u2010shape pattern between BMI and HRQL with a peak of 22\u201323\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was found, in which the odd ratio per 1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      increase in BMI was 0.98 (95% CI 0.98, 0.99) below 22\u201323\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and 1.03 (95% CI 1.03\u20131.03) above this point.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found distinct ranges of BMI for minimized mortality risk and maximized HRQL. The BMI range corresponding to the HRQL is lower than the BMI range corresponding to the lowest risk of death generally. Therefore, it is worth considering how to define the new recommended range for a new BMI based on the goal of \u2018living a longer and healthier life\u2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16325","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T05:59:33Z","timestamp":1741931973000},"page":"3132-3144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of\n                    <scp>BMI<\/scp>\n                    with mortality and health\u2010related quality of life among 4.4 million adults: Evidence from a nationwide, population\u2010based, prospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2887-699X","authenticated-orcid":false,"given":"Yi","family":"Wu","sequence":"first","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Lin","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5929-4571","authenticated-orcid":false,"given":"Chunqi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runsi","family":"Wang","sequence":"additional","affiliation":[{"name":"General Office of the Institute of Clinical Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolin","family":"Jin","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowang","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlan","family":"Cui","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Song","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"He","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing People's Republic of China"},{"name":"Fuwai Hospital Chinese Academy of Medical Sciences  Shenzhen People's Republic of China"},{"name":"Central China Sub\u2010Center of the National Center for Cardiovascular Diseases  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487320908983"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.12.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21499"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdr042"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i2156"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.113905"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1042"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30288-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-134"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00179-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-9-53"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955\u2010015\u20100347\u20109"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.252"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyad074"},{"key":"e_1_2_11_18_1","unstructured":"National Bureau of Statistics.How to distinguish between permanent population and floating population.2023. Accessed February 18 2024.https:\/\/www.stats.gov.cn\/zs\/tjws\/tjbz\/202301\/t20230101_1903796.html"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2014.05.007"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.123.010673"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(23)00244-X"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34160"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155744"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30488-1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0176"},{"key":"e_1_2_11_26_1","volume-title":"IARC Handbooks of Cancer Prevention","author":"International Agency for Research on Cancer","year":"2002"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24527"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23719"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.01.007"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.10.4161"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06096.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00511.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390600550299"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715768909087933"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002970"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00966"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-12009-8"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.268"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.07.020"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00374.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.186726"},{"issue":"6","key":"e_1_2_11_42_1","first-page":"620","article-title":"Association of body mass index and depressive symptoms in a Chinese community population: results from the health promotion knowledge, attitudes, and performance survey in Taiwan","volume":"34","author":"Yu NW","year":"2011","journal-title":"Chang Gung Med J"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04182.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210384"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114187"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00431-8"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01147-13"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102615"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00570-4"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba3066"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(24)00043\u20104"},{"issue":"7","key":"e_1_2_11_52_1","first-page":"687","article-title":"Study on the relationship between body mass index and health\u2010related quality of life in middle\u2010aged or older Chinese adults","volume":"30","author":"Zhu YB","year":"2009","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.07.049"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13091300"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:55:32Z","timestamp":1761893732000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.16325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/dom.16325"],"URL":"https:\/\/doi.org\/10.1111\/dom.16325","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.16325\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16325\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16325\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16325\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16325\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16325\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16325\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"2025-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}