{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:09:38Z","timestamp":1791806978241,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>We assessed the prevalence of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and significant liver fibrosis in adults with type 1 diabetes mellitus (T1DM) and the association of MASLD with insulin sensitivity and continuous glucose monitoring metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We consecutively enrolled 198 adults with T1DM undergoing vibration\u2010controlled transient elastography with liver stiffness measurement (LSM) and controlled attenuation parameter (CAP). All participants had a continuous glucose monitoring (CGM) device. Insulin sensitivity was evaluated by estimated glucose disposal rate (eGDR). MASLD was defined as CAP \u2265\u2009248\u2009db\/m and the presence of at least one cardiometabolic risk factor. Significant liver fibrosis was defined as LSM \u2265\u20097\u2009kPa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients had a mean age of 56\u2009years, mean BMI of 26.0\u2009\u00b1\u20095.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and mean eGDR of 7.1\u2009\u00b1\u20092.3\u2009mg\/kg\/min. 73 (37%) patients had MASLD (using a CAP threshold of 274\u2009dB\/m), 16 (8.1%) of whom had significant liver fibrosis. MASLD was associated with a significantly lower eGDR (beta coefficient\u2009=\u2009\u22120.367, 95% confidence interval \u22120.472 to \u22120.261;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). This association remained significant, even after adjustment for age, sex, body mass index, plasma triglycerides, diabetes duration, daily insulin dose, time above the range of glucose levels, LSM and chronic kidney disease. No association was observed between MASLD and CGM\u2010derived metrics. These results were not different when we used a CAP threshold of 274\u2009dB\/m for diagnosing MASLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In T1DM, MASLD was inversely associated with eGDR and biomarkers of insulin resistance but not with CGM\u2010derived metrics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16333","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T01:19:56Z","timestamp":1741915196000},"page":"3201-3211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic dysfunction\u2010associated steatotic liver disease, insulin sensitivity and continuous glucose monitoring metrics in patients with type 1 diabetes: A multi\u2010centre cross\u2010sectional study"],"prefix":"10.1111","volume":"27","author":[{"given":"Michela","family":"Vergani","sequence":"first","affiliation":[{"name":"Department of Medicine and Rehabilitation Policlinico di Monza  Monza Italy"},{"name":"School of Medicine and Surgery University of Milano Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2 Diego","family":"Borella","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Rehabilitation Policlinico di Monza  Monza Italy"},{"name":"School of Medicine and Surgery University of Milano Bicocca  Milan 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