{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:01:47Z","timestamp":1787626907857,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001509","name":"Royal Society Te Ap\u0101rangi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the associations of intra\u2010pancreatic fat deposition (IPFD) with very\u2010low\u2010density lipoprotein (VLDL), intermediate\u2010density lipoprotein (IDL) and lipoprotein lipase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A total of 174 participants underwent magnetic resonance imaging on a 3.0 Tesla scanner for the quantification of IPFD. Blood samples were collected following an 8\u2010h fasting period. Triglyceride\u2010rich lipoproteins were measured using the Lipoprint\u00ae system and classed as VLDL, IDL\u2010C, IDL\u2010B and IDL\u2010A subfractions. Lipoprotein lipase was measured using ELISA. Univariable and multivariable linear regression analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both IPFD and lipoprotein lipase were significantly associated with the levels of IDL\u2010B in the most adjusted model. Specifically, each unit increase in IPFD was associated with a 0.12\u2010unit increase in IDL\u2010B (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) whereas each unit increase in lipoprotein lipase was associated with a 0.22\u2010unit increase in IDL\u2010B (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Neither IPFD nor lipoprotein lipase was associated with VLDL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The relationship of IPFD with triglyceride\u2010rich lipoproteins differs depending on the nature of the lipoproteins. High IPFD is significantly associated with increased levels of IDL (specifically, its most representative subfraction\u2014IDL\u2010B), but not VLDL. Fatty pancreas disease may contribute to increasing the risk of atherosclerotic CVD through IDL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16338","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T05:59:16Z","timestamp":1741931956000},"page":"3233-3241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Associations of intra\u2010pancreatic fat deposition with triglyceride\u2010rich lipoproteins and lipoprotein lipase"],"prefix":"10.1111","volume":"27","author":[{"given":"Yutong","family":"Liu","sequence":"first","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"Skudder\u2010Hill","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandia","family":"Kimita","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiatiguli","family":"Shamaitijiang","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana R.","family":"Sequeira\u2010Bisson","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Biological Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-9062","authenticated-orcid":false,"given":"Maxim S.","family":"Petrov","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1288"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs431"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1026"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.253757"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25432"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2023.38.e295"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90920.2008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.134"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00064-X"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02022-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15550"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2019.06.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2024.103052"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13914"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2023.102881"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15990"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15233"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02355-y"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00551-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24154"},{"issue":"3","key":"e_1_2_10_23_1","first-page":"293","article-title":"Comparative use of three different laboratory methods to investigate a paradigmatic case of severe genetic dysbetalipoproteinemia","volume":"12","author":"Gaddi A","year":"2019","journal-title":"Med J Nutr Metab"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.07.009"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051422"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.816181"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319717744315"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000022015.97341.3A"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13523"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174660"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934141"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15281"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0976"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101428"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0446-1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.06.032"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.06.023"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.610"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1942"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100355"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000330"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39764-9"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00252"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.756057"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.4.534"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5685"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200210000-00001"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000143859.75035.5a"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61177-6"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.6.1.79"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00408-1"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(86)28084-2"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38178-5"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12134399"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2022.402"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39880-1"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(91)90079-I"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.2.5.396"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1980.tb02090.x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(87)80027-7"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(95)06032-3"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq0102.101551"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.4.622"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.7.768"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.6.819"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.6.1405"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.3.616"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05606-8"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(93)90219-Y"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05793-4"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2023.101343"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:55:42Z","timestamp":1761893742000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.16338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/dom.16338"],"URL":"https:\/\/doi.org\/10.1111\/dom.16338","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"2025-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}