{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:29:35Z","timestamp":1791232175076,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the clinical and biochemical characteristics of individuals with renal glucosuria to matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We analysed data from 60,000 consecutive adults in Maccabi Healthcare Services, an Israeli health maintenance organization, who had at least two urine dipstick tests performed at least 3\u2009months apart within 10\u2009years before 11 March 2024. For each patient, we analysed the most recent urine test and the previous test taken at least 3\u2009months earlier. We excluded individuals with prediabetes or diabetes, sodium\u2010glucose cotransporter 2 inhibitor use and pregnancy. Individuals with renal glucosuria (two positive glucose urine tests plus an ICD\u20109\u2010CM diagnosis) were matched 1:3 to controls (two negative glucose urine tests) by age, sex, weight and BMI. Clinical and laboratory data were assessed using univariate and multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 227 individuals with renal glucosuria, 220 were matched with 660 controls selected from a total of 33,655 individuals. The mean age of the study population (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009880) was 36.9\u2009\u00b1\u200912\u2009years; 70% were female, and the mean BMI was 24.1\u2009\u00b1\u20094.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Individuals with renal glucosuria had higher haematocrit (adjusted odds ratio [aOR] 1.10, 95% confidence interval [CI] 1.04 to 1.16) and lower blood uric acid levels (aOR 0.70, 95% CI 0.58 to 0.85) compared with controls. No significant differences were observed in fasting glucose, estimated glomerular filtration rate, lipid profiles or the rates of hypertension, atherosclerotic cardiovascular disease or genitourinary infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In young adults, renal glucosuria was associated with higher haematocrit and lower uric acid, with no other cardiometabolic differences from controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16339","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T03:08:51Z","timestamp":1742180931000},"page":"3242-3251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and biochemical profile of individuals with renal glucosuria: A matched cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1206-1516","authenticated-orcid":false,"given":"Afif","family":"Nakhleh","sequence":"first","affiliation":[{"name":"Diabetes and Endocrinology Clinic Maccabi Healthcare Services  Haifa Israel"},{"name":"Institute of Endocrinology Diabetes and Metabolism, Rambam Health Care Campus  Haifa Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limor","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Health Maccabi Healthcare Services  Tel Aviv Israel"},{"name":"Family Medicine Department, Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gida","family":"Ayada","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology Diabetes and Metabolism, Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Shapiro Ben David","sequence":"additional","affiliation":[{"name":"Division of Health Maccabi Healthcare Services  Tel Aviv Israel"},{"name":"Family Medicine Department, Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Rahamim\u2010Cohen","sequence":"additional","affiliation":[{"name":"Division of Health Maccabi Healthcare Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Liran","sequence":"additional","affiliation":[{"name":"Division of Health Maccabi Healthcare Services  Tel Aviv Israel"},{"name":"Family Medicine Department, Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagit","family":"Zolotov","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Clinic Maccabi Healthcare Services  Haifa Israel"},{"name":"Institute of Endocrinology Diabetes and Metabolism, Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim","family":"Shehadeh","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Clinic Maccabi Healthcare Services  Haifa Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed 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