{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:58:07Z","timestamp":1792069087645,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY033359"],"award-info":[{"award-number":["R01EY033359"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY019007"],"award-info":[{"award-number":["P30EY019007"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This retrospective cross\u2010sectional study, using retinal spectral\u2010domain optical coherence tomography (SD\u2010OCT) scans, investigated obesity\u2010related structural alterations in the retina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Ninety\u2010two eyes of 92 healthy asymptomatic participants were categorized into two groups based on body mass index (BMI) measurements: non\u2010obese (BMI\u2009&lt;\u200925, 45%) and pre\u2010obese\/obese (BMI \u2265 25, 55%) to compare imaging parameters of different retinal layers. Structural parameters, including thickness and volume values, were obtained across distinct retinal layers segmented on SD\u2010OCT scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The retinal nerve fibre layer volume was lower in the high\u2010BMI group than in the low\u2010BMI group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). However, the high\u2010BMI group presented significantly higher inner nuclear layer volume than the low\u2010BMI group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). In the region analysis, the retinal nerve fibre layer volume difference was prominent in the superior (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) and inferior (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) parafoveal and nasal perifoveal (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) regions, while inner nuclear layer changes were prominent in the inferior (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) perifoveal regions. A stepwise hierarchical binary logistic regression model, controlling for age and gender, pointed to significant associations of the regionally decreased retinal nerve fibre layer volume and increased inner nuclear layer volume with high BMI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Retinal SD\u2010OCT imaging detected structural alterations in distinct retinal layers between healthy, asymptomatic individuals in non\u2010obese and pre\u2010obese\/obese groups. Besides a decreased volume of the retinal nerve fibre layer, a significant increase was detected in the inner nuclear layer volume with a high BMI, possibly due to M\u00fcller glia responses to obesity\u2010related osmotic, metabolic and inflammatory stress, awaiting further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16344","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T07:06:50Z","timestamp":1742713610000},"page":"3262-3273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Obesity\u2010related early structural alterations in the retina detected by optical coherence tomography"],"prefix":"10.1111","volume":"27","author":[{"given":"Maide G\u00f6zde","family":"\u0130nam","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Edward S. Harkness Eye Institute, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"\u0130nam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Edward S. Harkness Eye Institute, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center  New York New York USA"},{"name":"Department of Biophysics, Faculty of Medicine Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doru","family":"Gucer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Edward S. Harkness Eye Institute, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Edward S. Harkness Eye Institute, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasseen","family":"Amellal","sequence":"additional","affiliation":[{"name":"Medical College of Georgia  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongalp H.","family":"Tezel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Edward S. Harkness Eye Institute, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-979X","authenticated-orcid":false,"given":"G\u00fclg\u00fcn","family":"Tezel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Edward S. 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