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Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring. Advances in measurement techniques and evidence from large\u2010scale studies have reinforced its prognostic value, particularly in guiding interventions such as renin\u2010angiotensin\u2010aldosterone system blockade, sodium\u2010glucose cotransporter\u20102 inhibitors and non\u2010steroidal mineralocorticoid receptor antagonists. Albuminuria assessment is now integrated into CKD staging, cardiovascular risk prediction models and therapy selection. Despite its established utility, challenges remain, including measurement variability, assay standardisation and under\u2010utilisation in clinical practice. This review provides a practical update on albuminuria testing, summarising its historical development, technical aspects and clinical implications, and emphasising its role in CKD management and cardiovascular risk assessment.<\/jats:p>","DOI":"10.1111\/dom.16359","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T15:13:46Z","timestamp":1743261226000},"page":"15-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease\u2014A practical update for clinicians"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-9012","authenticated-orcid":false,"given":"Jelle M.","family":"Beernink","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology University Medical Centre Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"van Mil","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology University Medical Centre Groningen, University of Groningen  Groningen the Netherlands"},{"name":"Department of Nephrology University Medical Centre Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozewijn D.","family":"Laverman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Nephrology Ziekenhuis Groep Twente  Almelo the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-3730","authenticated-orcid":false,"given":"Hiddo J. 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