{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:04:48Z","timestamp":1793747088226,"version":"4.6.1"},"reference-count":140,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974107"],"award-info":[{"award-number":["81974107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270909"],"award-info":[{"award-number":["82270909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether the antidiabetic agent glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) can exert anti\u2010inflammatory effects while lowering blood glucose, we performed a meta\u2010analysis and systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched 4 online databases (Medline, Embase, Cochrane Library and the Web of Science) for randomised controlled trials (RCTs) that examined changes after GLP\u20101RAs intervention in commonly accepted biomarkers of inflammation: C\u2010reactive protein (CRP), tumour necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), interleukin\u20101\u03b2 (IL\u20101\u03b2), leptin, adiponectin, plasminogen activator inhibitor\u20101 (PAI\u20101), monocyte chemotactic protein\u20101(MCP\u20101) and advanced glycation end products (AGEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This meta\u2010analysis included 52 eligible RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094734) with a median follow\u2010up of 24\u2009weeks, a mean age of 54.13\u2009years, 44.46% females, body mass index (BMI) 29.80\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , glycated haemoglobin (HbA1c) 8.28% and diabetes duration 7.27\u2009years. GLP\u20101 RAs treatment, compared to placebo or conventional diabetes therapies (including oral medicine and insulin), resulted in significant reductions in CRP, TNF\u2010\u03b1, IL\u20106, IL\u20101\u03b2 and leptin (standard mean difference [SMD] \u22120.63 [\u22121.03, \u22120.23]; SMD \u20100.92 [\u22121.57, \u22120.27]; SMD \u20100.76 [\u22121.32, \u22120.20], SMD \u20103.89 [\u22126.56, \u22121.22], SMD \u20100.67 [\u22121.09, \u22120.26], respectively), as well as significant increases in adiponectin (SMD 0.69 [0.19, 1.19]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our meta\u2010analysis demonstrates that GLP\u20101 RAs exert significant anti\u2010inflammatory effects in patients with T2DM. Our findings provide important insights that may guide the therapeutic application of GLP\u20101 RAs and inform the development of related therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16366","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T03:08:31Z","timestamp":1744686511000},"page":"3607-3626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["The effect of\n                    <scp>GLP<\/scp>\n                    \u20101 receptor agonists on circulating inflammatory markers in type 2 diabetes patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3295-5049","authenticated-orcid":false,"given":"Yifan","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-8809","authenticated-orcid":false,"given":"Wen","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Diabetes and Metabolic Disease Clinical Research Center of Hubei Province  Wuhan China"},{"name":"Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging  Wuhan China"},{"name":"Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab484"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008720"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)61350\u20105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034645"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034032"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883\u2010020\u201000883\u20103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.06.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161230142931"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac444"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32225\u20106"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26174"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.812"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.62"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.3.327"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2925"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010016\u20100303\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29069"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2021.06.001"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010023\u201002585\u20104"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.958790"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010007\u20100007\u20106"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.05.037"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(21)00203\u20105"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010026"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.427"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i40.14821"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016663218"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.153732"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.11.009"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14399"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u2010S062"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2023.11948"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1088187"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010022\u201001634\u20101"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14343"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201099527\u2010y"},{"key":"e_1_2_11_39_1","first-page":"1325","article-title":"Effects and characteristics of liraglutide and its correlation with intestinal microflora in patients with type 2diabetes","volume":"16","author":"Li J","year":"2021","journal-title":"Journal of Pathogen Biology"},{"key":"e_1_2_11_40_1","first-page":"400","article-title":"Clinical trial of liraglutide in the treatment of patients with type 2 diabetes mellitus and non\u2010alcoholic fatty liver","volume":"36","author":"Jiang Z","year":"2020","journal-title":"Chin J Clin Pharmacol"},{"key":"e_1_2_11_41_1","first-page":"1453","article-title":"Clinical trial of liraglutide injection combined with metformin tablets in the treatment of patients with type 2 diabetes mellitus and obesity","volume":"36","author":"Sun N","year":"2020","journal-title":"Chin J Clin Pharmacol"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431X20198652"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010020\u201001014\u20107"},{"key":"e_1_2_11_44_1","first-page":"2765","article-title":"Clinical trial of liraglutide combined with insulin injection in the treatment of patients with type 2 diabetes mellitus","volume":"36","author":"Zhao Z","year":"2020","journal-title":"Chin J Clin Pharmacol"},{"key":"e_1_2_11_45_1","first-page":"1219","article-title":"Comparison between the effects of sitagliptin and liraglutide on blood glucose and cognitive function of patients with both type 2 diabetes mellitus and post\u2010stroke mild cognitive impairment","volume":"13","author":"Wang Q","year":"2020","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.07.007"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.324"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6423987"},{"key":"e_1_2_11_49_1","first-page":"2549","article-title":"A prospective randomized control study on effect of liraglutide on cardiovascular outcomes in type II diabetes mellitus","volume":"12","author":"Pavithra D","year":"2019","journal-title":"Drug Invention Today"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2018.08.010"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2682657"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30320"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010018\u20100701\u20104"},{"key":"e_1_2_11_54_1","first-page":"2803","article-title":"Clinical trial of liraglutide injection in the treatment of patients with overweight and obese type 2 diabetes mellitus complicated with microalbuminuria","volume":"34","author":"Jian X","year":"2018","journal-title":"Chin J Clin Pharmacol"},{"key":"e_1_2_11_55_1","first-page":"780","article-title":"Clinical trial of liraglutide injection in the treatment of patients with diabetes mellitus","volume":"34","author":"Li F","year":"2018","journal-title":"The Chinese Journal of Clinical Pharmacology"},{"issue":"6","key":"e_1_2_11_56_1","first-page":"1141","article-title":"Assessment of complex treatment influence on systemic inflammation in overweight type 2 diabetes patients","volume":"71","author":"Said OV","year":"2018","journal-title":"Wiad Lek"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20181304"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010018\u20100392\u20108"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16\u20100449"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20160803"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4863"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2017.01.003"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12884"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010017\u20100609\u20100"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.12.003"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12680"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.03.009"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16\u20101133"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16968"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010015\u20100279\u2010z"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12269"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010014\u20100638\u20103"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.09.046"},{"key":"e_1_2_11_74_1","first-page":"211","article-title":"Greater efficacy and improved endothelial dysfunction in untreated type 2 diabetes with liraglutide versus sitagliptin","volume":"41","author":"Suzuki K","year":"2014","journal-title":"Dokkyo J Med Sci"},{"key":"e_1_2_11_75_1","first-page":"270","article-title":"Efficacy and safety of liraglutide versus insulin in overweight and obese patients with type 2 diabetes mellitus","volume":"5","author":"Chen R","year":"2013","journal-title":"Chin J Diabetes Mellitus"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u201027302013000900005"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.04.005"},{"key":"e_1_2_11_78_1","first-page":"3339","article-title":"Effect of liraglutide in patients with type 2 diabetes and obesity and on their micro \u2010 inflammation","volume":"16","author":"Xi Y","year":"2013","journal-title":"Chin Gen Pract"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2012.03699.x"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2012.03589.x"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.152"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2010.0048"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09\u20102361"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2009.0141"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2008.02484.x"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_87_1","unstructured":"HigginsJPT GrenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration Available from handbook.cochrane.org. [updated March 2011]2011."},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u2010135"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u20108\u201056"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.05.051"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018814559725"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12020183"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010022\u201001474\u2010z"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034516"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.05.012"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)32261\u2010x"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1514009"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010016\u20100480\u20108"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164113481817"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi20\u20100049"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106320"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3145-0"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20101508"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143393"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1056\u20108727(02)00176\u20109"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1303076"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2020.140475"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16\u20101860"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.7326\/m23\u20102788"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23\u20101490"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00604.2020"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.05.004"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.04.015"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018821997320"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(09)60659\u20100"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20102760"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010020\u201001070\u2010z"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.Hyp.0000221429.94591.72"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.Atv.0000201938.78044.75"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1566"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1347"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741\u2010024\u201010450\u20106"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.11.009"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00463.2010"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31821e5626"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.041418"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20101544"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.09.004"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010020\u201001049\u2010w"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.08.004"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.08.006"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501352"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.009"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.114.301958"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.183"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100675\u20100"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:40:14Z","timestamp":1761889214000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.16366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":140,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/dom.16366"],"URL":"https:\/\/doi.org\/10.1111\/dom.16366","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.16366\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v5\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v4\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v5\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v5\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16366\/v4\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"2024-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}