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Numerous concordant animal and human studies suggest that GLP\u20101RAs could reduce the risk of addiction, especially alcohol use disorders (AUD). This comprehensive review aims at summarising the known effects of GLP\u20101RAs on AUD. An extensive literature search detected clinical (either observational or controlled) studies that investigated the prevalence and severity of AUD in obese\/T2DM patients treated with GLP\u20101RAs compared with a control group. In seven observational cohort studies (12 paired data for comparisons), the prevalence of AUD was reduced by 35% (hazard ratio 0.65; 95% confidence interval 0.56\u20130.74) with GLP\u20101RA therapy when compared to no\u2010GLP\u20101 therapy. The protection by GLP\u20101RAs concerned both incidence and recurrence of AUD. These positive human findings confirm preclinical data in rodents and monkeys. Some genetic, experimental and functional neuroimaging human studies also supported a potential role of the GLP\u20101 system in the alcohol\u2010related reward process. Only two randomised controlled trials are available yet with inconclusive results, but several are ongoing to confirm the protective effect of semaglutide on AUD. Different neuronal and psychological mechanisms involving the reward pathways are proposed to explain the favourable findings reported with GLP\u20101RAs. In conclusion, available data from observational cohort studies showed a concordant and significantly reduced risk of AUD and alcohol consumption habits with GLP\u20101RA therapy. However, further studies are required before considering any indication of GLP\u20101RAs for the prevention or management of AUD.<\/jats:p>","DOI":"10.1111\/dom.16453","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:24:26Z","timestamp":1747185866000},"page":"4083-4091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Glucagon\u2010like peptide\u20101 receptor agonists and alcohol use disorders: An emerging unexpected beneficial effect"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-4371","authenticated-orcid":false,"given":"Andr\u00e9 J.","family":"Scheen","sequence":"first","affiliation":[{"name":"Division of Diabetes, Nutrition and Metabolic Disorders CHU Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"Division of Clinical Pharmacology, Centre for Interdisciplinary Research on Medicines (CIRM) Li\u00e8ge University  Li\u00e8ge 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