{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:40:19Z","timestamp":1787593219834,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 112\u20102628\u2010B\u2010006\u2010008\u2010MY3"],"award-info":[{"award-number":["MOST 112\u20102628\u2010B\u2010006\u2010008\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Diabetic foot ulcers (DFUs) impose a vast health and economic burden on individuals and healthcare systems globally. We assessed the cost\u2010effectiveness of adding ON101, a novel treatment for accelerating wound healing, to general wound care (GWC) versus GWC alone for DFUs in Singapore, a multi\u2010ethnic country with increasing DFU prevalence in a growing type 2 diabetes population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A Markov model was utilized to estimate the healthcare costs and quality\u2010adjusted life years (QALYs) over 5\u2009years from a healthcare sector perspective. Model inputs were mainly derived from the Singapore Wound Registry and published literature. The primary outcome was the incremental cost\u2010effectiveness ratio (ICER). Subgroup analyses stratified by clinically important DFU conditions and scenario analyses were conducted to confirm the study's robustness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to GWC alone, adding ON101 yielded greater QALY gained (i.e., 0.15) and lower healthcare costs (i.e., \u2212US$16237) for patients with DFUs. Remarkable cost\u2010savings from the use of ON101 with GWC were observed for patients with complex DFUs, namely ICERs of \u2212US$161 963, \u2212US$181 726 and \u2212US$199 130 per QALY gained for cases with HbA1c \u2265\u20099%, ulcer duration &gt;6\u2009months and ulcer size &gt;5\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      , respectively. Scenario analysis comparing ON101 with GWC to negative pressure wound therapy with GWC yielded an ICER of \u2212US$677 243 per QALY gained.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combining ON101 with GWC versus GWC alone was highly cost\u2010effective for DFUs in Singapore. Also, the economic results for complex DFU cases underscore the value of ON101 in addressing DFU treatment challenges for managing complex cases, offering cost\u2010savings alongside clinical benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16473","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:44:44Z","timestamp":1747809884000},"page":"4344-4353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cost\u2010effectiveness of\n                    <scp>ON101<\/scp>\n                    with general wound care for diabetic foot ulcers among patients with type 2 diabetes in Singapore: Analysis of a multi\u2010ethnic country in Asia"],"prefix":"10.1111","volume":"27","author":[{"given":"Hsuan\u2010Yu","family":"Su","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khong\u2010Yik","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery SingHealth, Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Graves","sequence":"additional","affiliation":[{"name":"Health Services and Systems Research Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-7848","authenticated-orcid":false,"given":"Huang\u2010Tz","family":"Ou","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Pharmacy College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22\u20100043"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20102176"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275920"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.22607"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2023.0167"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.1265"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.50639"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.03.1795"},{"key":"e_1_2_10_12_1","unstructured":"International Diabetes Federation.IDF diabetic foot report. International Diabetes Federation.2022.https:\/\/diabetesatlas.org\/idfawp\/resource\u2010files\/2022\/12\/IDF\u2010Diabetic\u2010Foot\u2010Report.pdf. Accessed November 8 2024."},{"key":"e_1_2_10_13_1","unstructured":"Agency for Care Effectiveness.Drug and Vaccine Evaluation Methods and Process Guide Version 3.1.2023. Agency for Care Effectiveness.https:\/\/www.ace-hta.gov.sg\/docs\/default-source\/process-methods\/drug-and-vaccine-evaluation-methods-and-process-guide-version-3-1-(september-2023).pdf?sfvrsn=2c01b7fa_10. Accessed November 8 2024."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3657"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102021\u2010067975"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.70146"},{"key":"e_1_2_10_17_1","unstructured":"Smart Wealth.Medical inflation rate in Singapore. Smart Wealth.2024.https:\/\/smartwealth.sg\/medical\u2010inflation\u2010rate\u2010singapore\/. 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