{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:54:45Z","timestamp":1790456085364,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020948","name":"AstraZeneca M\u00f6lndal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We assessed the effects of dapagliflozin on natriuresis and blood pressure in patients with type 2 diabetes and chronic kidney disease (CKD) and evaluated the consistency of these effects across patients with type 2 diabetes without CKD and CKD without type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a mechanistic, nonrandomised, open\u2010label study to evaluate the effects of dapagliflozin on sodium excretion and blood pressure in patients with type 2 diabetes and CKD under a standardised sodium intake (150\u2009mmol\/day). Evaluations were performed at baseline (average of Days \u22123 to \u22121), treatment start (average of Days 2\u20134; hereafter referred to as Day 4), treatment end (average of Days 12\u201314; hereafter referred to as Day 14) and washout (average of Days 15\u201317). Similar protocols were applied to the type 2 diabetes without CKD and CKD without type 2 diabetes strata. Data from all strata were pooled to assess the consistency of the effects of dapagliflozin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 13 participants with type 2 diabetes and CKD, 24\u2010h sodium excretion did not increase during treatment, as reflected by changes from baseline (Day 4 change: \u20130.5\u2009mmol\/24\u2010h [95% CI \u201315.4, 14.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.95; Day 14 change: \u201311.7\u2009mmol\/24\u2010h [95% CI \u201330.4, 7.1]). Compared to baseline, 24\u2010h systolic blood pressure decreased by 6.0\u2009mmHg [95% CI \u201319.8, 7.7] at Day 4 and by 3.7\u2009mmHg [95% CI \u201313.7, 6.2] at Day 14. In the pooled stratum of 33 participants, 24\u2010h sodium excretion remained unchanged relative to baseline (Day 4 change: \u20137.4\u2009mmol\/24\u2010h [95% CI \u201316.2, 1.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10; Day 14 change: \u201310.1\u2009mmol\/24\u2010h [95% CI \u201325.1, 5.0],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.18), whereas 24\u2010h systolic blood pressure was consistently reduced by 6.8\u2009mmHg ([95% CI \u201310.4, \u20133.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at Day 4 and by 6.5\u2009mmHg ([95% CI \u201310.1, \u20133.0],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at Day 14, with no evidence of heterogeneity across strata.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dapagliflozin reduced blood pressure during standardised sodium intake in patients with type 2 diabetes and\/or CKD without increasing sodium excretion, suggesting that the blood pressure\u2010lowering effects occur through mechanisms beyond natriuresis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16478","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:03:28Z","timestamp":1748581408000},"page":"4415-4426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of dapagliflozin on sodium excretion, blood pressure and volume status in patients with type 2 diabetes and\/or chronic kidney disease: The\n                    <scp>DAPASALT<\/scp>\n                    trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-9012","authenticated-orcid":false,"given":"Jelle M.","family":"Beernink","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Jongs","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte M.","family":"Mosterd","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Amsterdam University Medical Centers, Location VUMC, Diabetes Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie A.","family":"Scholtes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Amsterdam University Medical Centers, Location VUMC, Diabetes Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Caldwell\u2010McGee","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension Department of Medicine, University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Casillas","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension Department of Medicine, University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension Department of Medicine, University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Greasley","sequence":"additional","affiliation":[{"name":"Research and Early Development, Cardiovascular, Renal and Metabolism BioPharmaceuticals R&amp;D, AstraZeneca  Gothenburg M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Late\u2010Stage Development, Cardiovascular, Renal and Metabolism BioPharmaceuticals R&amp;D, AstraZeneca  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hammarstedt","sequence":"additional","affiliation":[{"name":"Late\u2010Stage Development, Cardiovascular, Renal and Metabolism BioPharmaceuticals R&amp;D, AstraZeneca  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7947-1822","authenticated-orcid":false,"given":"Vikas S.","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel H. A.","family":"Muskiet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Amsterdam University Medical Centers, Location VUMC, Diabetes Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozewijn D.","family":"Laverman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine ZGT Hospital  Almelo and Hengelo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-0429","authenticated-orcid":false,"given":"David Z. 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