{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:39:53Z","timestamp":1787593193555,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of once\u2010weekly tirzepatide in Japanese participants with obesity and type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This subpopulation analysis of 41 Japanese participants from three clinical trial sites in the SURMOUNT\u20102 trial evaluated the efficacy and safety of tirzepatide as an adjunct to lifestyle interventions in adults with body mass index \u226527\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and a diagnosis of T2D with glycated haemoglobin \u22657% to \u226410%. Coprimary endpoints were mean percent change in body weight and proportion of participants who achieved \u22655% body weight reduction at week 72. Percent change in body weight was compared between tirzepatide and placebo using a mixed model for repeated measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean percent change (standard error) in body weight from baseline to week 72 was statistically significantly greater for both tirzepatide 10\u2009mg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and 15\u2009mg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) compared with placebo: \u221212.4% (1.8%) and \u221210.2% (1.8%), respectively, compared with \u22123.5% (1.8%). At week 72, 85.7% and 78.6% of participants in the tirzepatide 10\u2009mg and 15\u2009mg groups, respectively, had a body weight reduction of \u22655%, versus 46.2% of participants receiving placebo. Reductions in glycemic parameters, waist circumference and systolic blood pressure, as well as numerical improvements in the lipid profile, were also observed with tirzepatide. No new safety concerns were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Japanese adults with obesity and T2D, once\u2010weekly treatment with tirzepatide (10 or 15\u2009mg) demonstrated significant reductions in body weight compared with placebo, with the safety profile generally consistent with previous studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16500","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T22:34:10Z","timestamp":1749508450000},"page":"4557-4566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of once\u2010weekly tirzepatide in Japanese participants with type 2 diabetes who have obesity or overweight: Subpopulation analysis of the\n                    <scp>SURMOUNT<\/scp>\n                    \u20102 trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4827-6404","authenticated-orcid":false,"given":"Toshimasa","family":"Yamauchi","sequence":"first","affiliation":[{"name":"Department of Diabetes and Metabolic Diseases Graduate School of Medicine, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Asakura","sequence":"additional","affiliation":[{"name":"Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic  Yamato Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1568-9763","authenticated-orcid":false,"given":"Tomotaka","family":"Shingaki","sequence":"additional","affiliation":[{"name":"Japan Drug Development and Medical Affairs Eli Lilly Japan K.K.  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0872-8576","authenticated-orcid":false,"given":"Tomonori","family":"Oura","sequence":"additional","affiliation":[{"name":"Japan Drug Development and Medical Affairs Eli Lilly Japan K.K.  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-3704","authenticated-orcid":false,"given":"Hideki","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism and Endocrinology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0415"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v3.i6.110"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ23-0593"},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization.Obesity: preventing and managing the global epidemic. Report of a WHO Consultation on Obesity. Geneva 3\u20105 June 1997.https:\/\/iris.who.int\/handle\/10665\/63854. 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