{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:44:27Z","timestamp":1788986667109,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100031224","name":"Nansenhjelpen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006133","name":"Anders Jahres Fond til Vitenskapens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Women who develop gestational diabetes mellitus (GDM) have a pancreatic \u03b2\u2010cell defect that cannot compensate for the insulin resistance of pregnancy. The glucose intolerance may, in addition to direct effects, negatively impact lipid metabolism, promote vascular dysfunction and contribute to cardiovascular disease (CVD). We assessed associations between oxidative stress and senescence markers with indices of glucose and lipid metabolism in women developing GDM and with CVD risk after 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The oxidative stress and senescence markers\n                      <jats:italic>NRF2, GPX4, TERC, XRN1<\/jats:italic>\n                      and\n                      <jats:italic>DCP2<\/jats:italic>\n                      were assessed in peripheral blood mononuclear cells (PBMCs), advanced oxidation protein products (AOPP) and \u03b2\u2010galactosidase in plasma, from healthy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009253) and women with GDM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931) during pregnancy and at 5\u2010year follow\u2010up, from the STORK study. We investigated their associations with established markers of disease activity and later CVD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma AOPP and \u03b2\u2010galactosidase were increased early in pregnancy in women developing GDM later and associated with indices of glucose metabolism and TG\/HDL\u2010Cholesterol. RNA levels of transcripts involved in telomer maintenance and antioxidant responses were decreased in women with GDM during pregnancy and at follow\u2010up. DCP2 and XRN1 expression were positively associated with \u03b2\u2010cell function at all timepoints and with pulse wave velocity at 5\u2010year follow\u2010up in women with previous GDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Markers of vascular oxidative stress and senescence are increased and correlate with indices of glucose and lipid metabolism early in pregnancy in women developing GDM. Cellular markers reflecting attenuated defence against oxidative stress and senescence decrease throughout pregnancy and at 5\u2010year follow\u2010up and correlate with aortic stiffness in women with previous GDM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16521","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:18:07Z","timestamp":1750209487000},"page":"4802-4811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxidative stress, senescence and\n                    <scp>mRNA<\/scp>\n                    decay in peripheral blood mononuclear cells of women with\n                    <scp>gestational diabetes mellitus<\/scp>\n                    \u2010link to increased\n                    <scp>cardiovascular disease<\/scp>\n                    risk"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-4726","authenticated-orcid":false,"given":"Tove","family":"Lekva","sequence":"first","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Cecilie Paasche","family":"Roland","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Department of Obstetrics Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Department of Medical Biochemistry Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Qvigstad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Division of Medicine, Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Khan","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Godang","sequence":"additional","affiliation":[{"name":"Division of Medicine, Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika E.","family":"Michelsen","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[{"name":"Research 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