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In the present review, we quote and discuss existing evidence on the effects of the major anti\u2010obesity medications on bone metabolism. Glucagon\u2010like peptide\u20101 receptor (GLP\u20101R) agonists have shown a positive impact in preclinical studies but a neutral or negative, albeit not clinically significant, effect on bone turnover markers and bone mineral density in clinical studies. Nevertheless, fracture risk does not seem to increase with GLP\u20101R agonists use, at least in clinically relevant doses. Limited, mostly preclinical, data suggest that other incretin analogues, including dual GLP\u20101R and glucose\u2010dependent insulinotropic polypeptide (GIP) receptor (GIPR) agonists, dual GLP\u20101R and glucagon receptor (GCGR) agonists, and triple GLP\u20101R, GIPR and GCGR agonists, may have a positive effect on bone. Preclinical data with amylin analogues imply the same. Activin type II receptor (ActRII) antagonists may combine anti\u2010obesity effects with simultaneous muscle and bone mass preservation and could be used either as monotherapy or in combination with incretin analogues. The bone effects of opioid receptor antagonists and setmelanotide are largely unknown, while the impact of the combination of phentermine with topiramate is assumed to be negative. Finally, very limited clinical evidence suggests that orlistat may have a neutral effect on bone metabolism.<\/jats:p>","DOI":"10.1111\/dom.16541","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T22:49:06Z","timestamp":1750805346000},"page":"4674-4688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The effects of anti\u2010obesity medications on bone metabolism: A critical appraisal"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9624-6296","authenticated-orcid":false,"given":"Athanasios D.","family":"Anastasilakis","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism 424 General Military Hospital  Thessaloniki 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