{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:36:30Z","timestamp":1790724990157,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,9]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n This cross\u2010sectional study examined associations between self\u2010reported taste perception changes and appetite\u2010related outcomes in individuals with obesity treated with glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101 RAS) or dual glucose\u2010dependent insulinotropic polypeptide (GIP)\/GLP\u20101 RAS in real\u2010world conditions.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Four hundred and eleven adults on Wegovy\u00ae (\n n<\/jats:italic>\n \u2009=\u2009217), Ozempic\u00ae (\n n<\/jats:italic>\n \u2009=\u2009148) and Mounjaro\u00ae (\n n<\/jats:italic>\n \u2009=\u200946) completed an online survey assessing sociodemographic, anthropometric and sensory changes and appetite\u2010related outcomes. Multivariable logistic regression was used to assess associations between taste changes and satiety, appetite and craving.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants (69.6% female; median age 39 [interquartile range,\n IQR<\/jats:styled-content>\n 33\u201347]) had baseline body mass index (\n BMI)<\/jats:styled-content>\n of 35.6 (Wegovy\u00ae), 34.7 (Ozempic\u00ae) and 36.2\u2009kg\/m\n 2<\/jats:sup>\n (Mounjaro\u00ae). Adjusted models for baseline\n BMI<\/jats:styled-content>\n , treatment duration, dose, age and sex showed significant reductions in\n BMI<\/jats:styled-content>\n of 17.6% (95%\n CI<\/jats:styled-content>\n : 15.7\u201319.5) for Wegovy\u00ae, 17.4% (15.0\u201319.8) for Ozempic\u00ae and 15.5% (8.8\u201322.2) for Mounjaro\u00ae. Reduced appetite was reported by 58.4% of participants (Wegovy\u00ae: 54.4%, Ozempic\u00ae: 62.1%, Mounjaro\u00ae: 56.5%) and increased satiety by 63.5% (Wegovy\u00ae: 66.8%, Ozempic\u00ae: 58.8%, Mounjaro\u00ae: 63.1%). Additionally, 21.3% reported increased sweet taste perception and 22.6% reported increased salty taste perception. Independent of the type of therapy, increased sweet taste perception was significantly associated with increased satiety (adjusted odds ratios [\n AOR]<\/jats:styled-content>\n \u2009=\u20092.02; 95%\n CI<\/jats:styled-content>\n : 1.15\u20134.57), decreased appetite (\n AOR<\/jats:styled-content>\n \u2009=\u20091.67; 95%\n CI<\/jats:styled-content>\n : 1.04\u20133.25) and decreased craving (\n AOR<\/jats:styled-content>\n \u2009=\u20091.85; 95%\n CI<\/jats:styled-content>\n : 1.05\u20133.29). Increased salty taste perception was associated with increased satiety (\n AOR<\/jats:styled-content>\n \u2009=\u20092.17; 95%\n CI<\/jats:styled-content>\n : 1.16\u20135.17; all\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Self\u2010reported changes in taste perception during GLP\u20101 or dual GIP\/GLP\u20101 RAS therapy were associated with favourable appetite\u2010related outcomes, suggesting a potential mechanism contributing to treatment response.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.16548","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T05:15:05Z","timestamp":1750742105000},"page":"5008-5018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Real\u2010world insights into incretin\u2010based therapy: Associations between changes in taste perception and appetite regulation in individuals with obesity and overweight: A cross\u2010sectional study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-0973","authenticated-orcid":false,"given":"Ali","family":"Kapan","sequence":"first","affiliation":[{"name":"Center for Public Health, Department of Social and Preventive Medicine Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-0685","authenticated-orcid":false,"given":"Othmar","family":"Moser","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine Medical University of Graz Graz Austria"},{"name":"Division of Exercise Physiology and Metabolism, Department of Sport Science University of Bayreuth Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-4218","authenticated-orcid":false,"given":"Richard","family":"Felsinger","sequence":"additional","affiliation":[{"name":"Center for Public Health, Department of Social and Preventive Medicine Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-8299","authenticated-orcid":false,"given":"Thomas","family":"Waldhoer","sequence":"additional","affiliation":[{"name":"Center for Public Health, Department of Epidemiology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-7332","authenticated-orcid":false,"given":"Sandra","family":"Haider","sequence":"additional","affiliation":[{"name":"Center for Public Health, Department of Social and Preventive Medicine Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375143"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010014\u20100243\u2010x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020212"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13717"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010024\u201001500\u2010y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2022.12.423"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1095753"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.09.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj2537"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.614884"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020902"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2008.05397.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae163.013"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2024.114793"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.6.3.e34"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.2525"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15802"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nsa.2023.103925"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23673"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010024\u201001981\u20105"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqae167"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706890104"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042617699"}],"container-title":["Diabetes, 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