{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:45:05Z","timestamp":1789393505486,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the weight fluctuation and explore its influencing factors after glucagon\u2010like peptide 1 receptor agonist (GLP\u20101RA) treatment in patients with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study enrolled 679 patients with overweight or obesity who initiated\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">1RA<\/jats:styled-content>\n                      treatment between November 2022 and October 2024. The weight measurements were collected during in\u2010person clinic visits by uniform weighing scales and documented in the electronic medical record (\n                      <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>\n                      ). The weight fluctuation curves were stratified into three phenotypes (Successful Weight Reduction, Remaining Stable and Weight Regain) and went through intergroup analyses. Subsequently, the association between potential influencing factors and weight fluctuations were estimated by univariate and multivariate logistic regression, where the weight fluctuation phenotypes were dichotomized into a binary variable, classified as \u201csuccessful weight reduction\u201d or \u201cunsuccessful weight reduction\u201d. Subgroup analyses were performed in participants with obesity, prediabetes, liraglutide users and semaglutide users.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with a longer duration of GLP\u20101RA treatment (OR\u2009=\u20091.014, 95% CI, 1.008\u20131.019) and higher HOMA\u2010\u03b2 (Homeostasis Model Assessment of \u03b2\u2010Cell Function) levels (OR\u2009=\u20094.912, 95% CI, 1.480 to 16.034) were more likely to achieve successful weight reduction at follow\u2010up of 12\u2009months. Non\u2010diabetic status (OR\u2009=\u20092.176, 95% CI, 1.242\u20133.812) and using semaglutide (OR\u2009=\u20092.138, 95% CI, 1.162\u20133.935) were associated with successful weight reduction at the follow\u2010up of 6\u2009months. Additionally, a higher percentage body fat (PBF) in both male (OR\u2009=\u20093.990, 95% CI, 1.118\u201314.246) and female (OR\u2009=\u20092.266, 95% CI, 1.179\u20134.354) was associated with successful weight reduction. The weight regain group had a higher baseline eGFR than other two groups at the 3\u2010month follow\u2010up especially in participants with prediabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Moreover, the J\u2010shaped associations of basal metabolic rate, skeletal muscle mass, abdominal and limb muscle mass with the probability of successful weight reduction within 6\u2009months, and a positive non\u2010linear association of serum creatinine with the probability of successful weight reduction within 12\u2009months have been characterized.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A longer duration of GLP\u20101RA treatment, using semaglutide, non\u2010diabetic status and higher PBF might be associated with better weight reduction. Basal metabolic rate, skeletal muscle mass, muscle mass of abdomen and limbs, and serum creatinine were non\u2010linearly associated with the probability of successful weight reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16552","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:01:07Z","timestamp":1752073267000},"page":"5042-5051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glucagon\u2010like peptide\u20101 receptor agonist treatment associated weight fluctuation and influencing factors in patients with overweight or obesity"],"prefix":"10.1111","volume":"27","author":[{"given":"Jingxuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-9831","authenticated-orcid":false,"given":"Chu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-0543","authenticated-orcid":false,"given":"Xiaoling","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjie","family":"Tie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuteng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0610-5121","authenticated-orcid":false,"given":"Wenjia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-2168","authenticated-orcid":false,"given":"Linong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12551"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15238"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3415"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.08.045"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00213-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076410","article-title":"Comparative effectiveness of GLP\u20101 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta\u2010analysis","volume":"384","author":"Yao H","year":"2024","journal-title":"BMJ"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1113"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01366-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403347"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.04.017"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411892"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03534-0"},{"key":"e_1_2_10_15_1","first-page":"9908","article-title":"Clinical effectiveness of semaglutide on weight loss, body composition, and muscle strength in Chinese adults","volume":"27","author":"Xiang J","year":"2023","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22462"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00739-z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1831"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13568"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12639"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00045-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.737"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15020"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15045"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11174938"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02385-x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2021.06.008"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.108931"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2007-2061"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-021-01141-8"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14468"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23859"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2022.100456"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13985"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.714173"},{"key":"e_1_2_10_36_1","first-page":"506","article-title":"Preoperative factors correlated with post\u2010bariatric surgery weight loss","volume":"87","author":"Stumpf M a M","year":"2022","journal-title":"Rev Gastroenterol Mex (Engl ed)"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23619"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2021.100082"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00020-9"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228984"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16012"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.6586"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.205591"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.11.2372"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802253180802"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0672-6"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:45:02Z","timestamp":1761875102000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.16552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/dom.16552"],"URL":"https:\/\/doi.org\/10.1111\/dom.16552","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.16552\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v4\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16552\/v4\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"2025-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}