{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:07:28Z","timestamp":1791630448875,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the impact of a temporary elevated glucose target (TT) on hypoglycaemia and glycaemic outcomes with exercise in adults with type 1 diabetes using an automated insulin delivery (AID) system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty\u2010six participants using the Medtronic MiniMed\u2122 780G system performed 16 exercise bouts: 12 afternoon bouts (four 40\u2009min and four 90\u2009min moderate\u2010intensity exercise [MIE] and four 40\u2009min high\u2010intensity interval exercise [HIE]) and four morning bouts of 40\u2009min MIE, with a TT set 60\u2009min (TT60), 20\u2009min (TT20), 0\u2009min (TT0) or no TT (TTnil) pre\u2010exercise. Oral carbohydrate was consumed pre\u2010exercise for glucose &lt;100\u2009mg\/dL and during exercise for sensor glucose &lt;70\u2009mg\/dL or symptomatic hypoglycaemia confirmed by fingerprick blood glucose. The primary outcome was time below range (TBR; &lt;70\u2009mg\/dL) from exercise commencement to 2\u2009h post\u2010exercise, with each TT condition compared with TT60 via sign rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary outcome, median TBR, was 0% from exercise commencement to 120\u2009min post\u2010exercise for all conditions with no difference between TT conditions. Insulin delivery in the 2\u2009h pre\u2010exercise was higher for TTnil compared to TT60 (1.3 [0.9, 2.4] Units vs. 2.0 [1.1, 3.0] Units;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013); however there was no difference between TT conditions for starting glucose, time in range (TIR) or for the number of participants who experienced a hypoglycaemia episode from exercise commencement to 2\u2009h post\u2010exercise.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Glycaemia with exercise was excellent regardless of TT timing, which had no measurable effect on TBR during and post\u2010exercise in a well\u2010controlled cohort in the absence of a recent meal.<\/jats:p>\n                  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