{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:19Z","timestamp":1787014099700,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is a prevalent and serious complication of type 2 diabetes (T2D). This study aims to evaluate kidney outcomes in a real\u2010world cohort of patients with T2D and CKD who received SGLT2 inhibitors (SGLT2i) or other glucose\u2010lowering medications (GLM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective, multicentre study analysed data from patients aged 18\u201380\u2009years with T2D and CKD, who initiated an SGLT2i or other GLM between 2015 and 2020. The primary outcome was the change in estimated glomerular filtration rate (eGFR) over time. Secondary outcomes included albuminuria changes and adverse kidney events. Propensity score matching was used to balance baseline characteristics between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092020\/group), patients (100% T2D with CKD) had a mean age of 63\u2009years, BMI 32\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , HbA1c 8.2%. New\u2010users of SGLT2i exhibited a slower decline in eGFR compared with new users of comparators (mean difference 1.43\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). Albuminuria improved significantly more in the SGLT2i group, with a greater likelihood of category improvement (hazard ratio [HR] 1.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). SGLT2i initiation was associated with a lower incidence of kidney outcomes, including a \u226540% eGFR reduction (HR 0.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). When the comparison was restricted to SGLT2i versus GLP\u20101RA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091266\/group), the eGFR slope was significantly better with SGLT2i (mean difference 0.62\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      \/year;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large, real\u2010world cohort, initiation of SGLT2i was associated with a significantly slower decline in kidney function and improved albuminuria compared with other diabetes drugs, including GLP\u20101RA. These findings support SGLT2i as the most effective T2D treatment to slow CKD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16569","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:17:46Z","timestamp":1751440666000},"page":"5182-5191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term preservation of kidney function with\n                    <scp>SGLT<\/scp>\n                    \u20102 inhibitors versus comparator drugs in people with type 2 diabetes and chronic kidney disease"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-2097","authenticated-orcid":false,"given":"Gian Paolo","family":"Fadini","sequence":"first","affiliation":[{"name":"Department of Medicine University of Padova  Padova Italy"},{"name":"Veneto Institute of Molecular Medicine  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Longato","sequence":"additional","affiliation":[{"name":"Department of Information Engineering University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Luca","family":"Morieri","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Broglio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Aimaretti","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Translational Medicine Universit\u00e0 del Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina T.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Anichini","sequence":"additional","affiliation":[{"name":"Diabetic Unit and Diabetic Foot Unit San Jacopo Hospital Pistoia  Pistoia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Ghiani","sequence":"additional","affiliation":[{"name":"Diabetology Unit Azienda Sanitaria Locale 8 Cagliari Quartu S. 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