{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:44:24Z","timestamp":1782823464124,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020013","name":"NIHR Leicester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effectiveness and safety of a fixed\u2010ratio combination of insulin glargine 100\u2009U\/mL and lixisenatide (iGlarLixi) over 24\u2009months in people with type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective, observational study, data were collected from the Optum Market Clarity\u00ae database in the United States. People with T2D aged \u226518\u2009years, previously treated with oral antidiabetic drugs \u00b1 basal insulin or glucagon\u2010like peptide\u20101 receptor agonists, who initiated iGlarLixi between 1 January 2017 and 31 March 2020 and received \u22651 iGlarLixi prescription were included. The primary outcome was change in HbA1c 24\u2009months after starting iGlarLixi. Secondary outcomes included change in HbA1c from baseline, achievement of HbA1c &lt;7%, change in body weight and rate of hypoglycaemia (defined as inpatient or outpatient claims, or blood glucose &lt;70\u2009mg\/dL) every 3\u2009months over 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 1685 people were included in this analysis (mean age, 58.4\u2009years; 52.6% female). In the overall population, including imputed values, mean\u2009\u00b1\u2009standard deviation (SD) baseline HbA1c (9.3\u2009\u00b1\u20091.8%) was reduced by 0.9% to 8.3\u2009\u00b1\u20091.8% at 24\u2009months. A HbA1c target of &lt;7% was achieved in 22.2% of people at 24\u2009months. Mean\u2009\u00b1\u2009SD body weight remained stable from baseline (102.1\u2009\u00b1\u200924.2\u2009kg) to 24\u2009months (101.9\u2009\u00b1\u200923.3\u2009kg). The hypoglycaemia event rate was 16.1 per 100 person\u2010years (P100PY) at baseline and decreased to 11.4 P100PY at 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iGlarLixi initiation was associated with improved glycaemic control, without body weight change or increased hypoglycaemia over 24\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16591","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:17:31Z","timestamp":1754896651000},"page":"5487-5497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term effectiveness of\n                    <scp>iGlarLixi<\/scp>\n                    treatment in people with type 2 diabetes in the United States: The soli\u2010durability 24\u2010month observational study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-8903","authenticated-orcid":false,"given":"Rayaz A.","family":"Malik","sequence":"first","affiliation":[{"name":"Research Division, Weill Cornell Medicine\u2010Qatar, Qatar Foundation Education City  Ar\u2010Rayyan Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Anderson","sequence":"additional","affiliation":[{"name":"The Frist Clinic  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed E. A.","family":"Amani","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Diabetes University of Ahmed BENBELLA, EHU  Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Ada\u015f","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Sanofi  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Lauand","sequence":"additional","affiliation":[{"name":"Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Sanofi  Bridgewater New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-7099","authenticated-orcid":false,"given":"Kamlesh","family":"Khunti","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-9028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0034"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1213829"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110672"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.12.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(95)01064-K"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806470"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S009"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13851"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14822"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0917"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1357"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12025"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0868-9"},{"key":"e_1_2_11_17_1","unstructured":"Sanofi.Suliqua: Summary of product characteristics.2017. 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