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We aimed to assess whether reducing sedentary behaviour in patients with metabolic syndrome impacts renal glucose uptake rate (GU) during insulin stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four participants with metabolic syndrome were randomized to receive either guidance to reduce sedentary behaviour (INT) by 1\u2009h\/day during a 6\u2010month intervention or to maintain usual sedentary behaviour (CONT). For this post\u2010hoc analysis, we included all participants with available renal data: 34 participants at baseline and 30 at the end of the intervention. Participants underwent\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodeoxyglucose positron emission tomography ([\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG\u2010PET) during a hyperinsulinemic clamp at baseline and at 6\u2009months. Renal [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG\u2010PET data were analysed using fractional uptake rate (FUR). A correction for the estimated residual amount of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG inside the tubuli was applied. Corrected GU was calculated as the product of FUR and glycemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the study end, light and moderate\u2010to\u2010vigorous physical activity (PA) were increased and BMI was slightly decreased, with no significant intervention effect. Cortical and medullary GU increased vs baseline, similarly in both groups. At baseline, cortical GU was directly related to the degree of insulin sensitivity and inversely to BMI and circulating FFA levels. Change in renal GU was directly related to change in liver GU, but not to the change in whole\u2010body insulin sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with metabolic syndrome, insulin\u2010stimulated renal GU increases concomitantly with a small decrease in body adiposity, independently of changes in whole\u2010body glucose disposal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16631","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T07:00:08Z","timestamp":1753167608000},"page":"5772-5781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of reducing sedentary behaviour on renal glucose uptake during insulin stimulation: A post\u2010hoc analysis of a 6\u2010month randomized controlled 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