{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:07:35Z","timestamp":1789056455457,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006453","name":"Taisho Toyama Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to determine the efficacy of oral administration of sodium\u2010glucose co\u2010transporter 2 inhibitors (SGLT2i) therapy for early diabetic macular oedema (DMO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a post\u2010hoc analysis of the COMET trial, a prospective, randomized, parallel, investigator\u2010driven protocol. Sixty patients with DMO eligible for anti\u2010vascular endothelial growth factor (VEGF) therapy were randomized to receive either the SGLT2i luseogliflozin or sulfonylurea (SU) glimepiride. Intravitreal ranibizumab (IVR) injections were administered per protocol to both eyes over 48\u2009weeks. For this analysis, we included eyes with no or mild macular oedema at baseline and excluded those that had received treatment within a defined period prior to enrolment. Best\u2010corrected visual acuity (BCVA), central retinal thickness (CRT), and the number of IVR injections were compared between the SGLT2i and SU groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, 20 eyes in the SU group and 22 eyes in the SGLT2i group did not require IVR. Changes in BCVA and CRT did not differ significantly between the groups. IVR was required in 9 of 20 eyes in the SU group versus 2 of 22 eyes in the SGLT2i group. The rate of the first IVR was significantly lower in the SGLT2i group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systemic SGLT2i therapy reduced the need for intravitreal anti\u2010VEGF treatment in eyes with early and mild DMO. These results suggest that SGLT2i may be effective in preventing the progression of early and mild DMO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16636","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T10:43:07Z","timestamp":1754304187000},"page":"5812-5821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sodium\u2010glucose co\u2010transporter 2 inhibitors reduce the intravitreal anti\u2010\n                    <scp>VEGF<\/scp>\n                    treatment necessity in eyes with early diabetic macular oedema: A post\u2010hoc analysis focusing on the fellow eye of the\n                    <scp>COMET<\/scp>\n                    trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-9403","authenticated-orcid":false,"given":"Tomoaki","family":"Tatsumi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science Chiba University Graduate School of Medicine  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-0934","authenticated-orcid":false,"given":"Yoko","family":"Takatsuna","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Chiba University Graduate School of Medicine  Chuo\u2010ku Chiba Japan"},{"name":"Department of Ophthalmology Chiba Rosai Hospital  Ichihara Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-5396","authenticated-orcid":false,"given":"Ryoichi","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Haematology, and Gerontology Chiba University Graduate School of Medicine  Chuo\u2010ku Chiba Japan"},{"name":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism Kimitsu Chuo Hospital  Kisarazu Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-9993","authenticated-orcid":false,"given":"Masaya","family":"Koshizaka","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolic Medicine Center for Preventive Medical Science, Chiba University  Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Kaiho","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Chiba University Graduate School of Medicine  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-845X","authenticated-orcid":false,"given":"Toshiyuki","family":"Oshitari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Chiba University Graduate School of Medicine  Chuo\u2010ku Chiba Japan"},{"name":"Department of Ophthalmology International University of Health and Welfare School of Medicine  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Shiko","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Graduate School of Medicine, Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Asaumi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Ophthalmology Kimitsu Chuo Hospital  Kisarazu Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Chiba University Graduate School of Medicine  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-4813","authenticated-orcid":false,"given":"Koutaro","family":"Yokote","sequence":"additional","affiliation":[{"name":"Chiba University  Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8178-8391","authenticated-orcid":false,"given":"Takayuki","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Chiba University Graduate School of Medicine  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.144550"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.06.017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.02.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.02.022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.6565"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2022.06.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022190"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1515920"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2017-000130"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.909708"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8867079"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12050692"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224549"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14445"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2022.0221"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.48431"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15454"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14253"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-024-01649-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2024.04.010"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2024.5219"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16244"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-020-00854-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.12.033"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61607-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001288"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2400179"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12214"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2024.100557"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64798-4"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.11.011"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2015.51.9.2368554"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(97)00071-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwx047"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.827896"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031362"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/db22-0970"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002004"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.012"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/full-xml\/10.1111\/dom.16636","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.16636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T06:19:43Z","timestamp":1771309183000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.16636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/dom.16636"],"URL":"https:\/\/doi.org\/10.1111\/dom.16636","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.16636\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.16636\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}