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These genes exhibited robust diagnostic potential (receiver operating characteristic area under the curve\u2009=\u20090.679\u20130.803), highlighting their utility as early AD biomarkers. Notably, OVO\u2010like zinc finger 2 (\n                      <jats:italic>OVOL2<\/jats:italic>\n                      ), a transcriptional repressor of glycolysis, was upregulated in AD and positively associated with tau burden and the suppression of\n                      <jats:italic>GPI<\/jats:italic>\n                      ,\n                      <jats:italic>PFKM<\/jats:italic>\n                      and\n                      <jats:italic>LDHA<\/jats:italic>\n                      . Functional studies demonstrated that OVOL2 knockdown restored glycolytic gene expression and attenuated tau pathology, suggesting that OVOL2 is a candidate upstream regulatory factor for AD metabolic disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, glycolysis enzymes were systemically altered in AD progression, and OVOL2 may be a candidate upstream regulator, while GPI, PFKM and LDHA may be potential diagnostic and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16641","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:09:38Z","timestamp":1753265378000},"page":"5852-5864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular signatures of brain glycolysis dysfunction in 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