{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:08:18Z","timestamp":1771312098786,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>(i) to identify patterns of chronic diseases using latent class analyses (LCA) and (ii) to examine their association with all\u2010cause mortality in the Mexico City Prospective Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>154\u2009369 participants (67.2% women) were included in this prospective analysis. From 17 self\u2010reported chronic conditions, four clusters were identified following a LCA approach: (a) Cluster 0 (63.3%), healthy group (reference group for the analyses); (b) Cluster 1 (7.5%), other chronic diseases: high prevalence of asthma, peptic ulcer, and peripheral artery disease; (c) Cluster 2 (21.0%), hypertension and some diabetes; (d) Cluster 3 (8.2%), mainly diabetes as the principal condition. Associations between the clusters and all\u2010cause mortality were investigated using Cox proportional hazard models adjusted for confounding factors. Sensitivity analyses were performed by sex and fulfilling the glycated haemoglobin (HbA1c) target for the cluster with the highest mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median follow\u2010up of 20\u2009years (IQR: 18.6\u201321.3), 30\u2009286 participants died. After adjusting, Cluster 3 (the diabetic cluster), where those with the highest mortality risk (hazard ratio [HR]: 2.60 [95% CI: 2.51\u20132.68]), followed by Cluster 2 (HR: 1.72 [1.67\u20131.77]) and Cluster 1 (HR: 1.26 [1.20\u20131.31]). Sensitivity analyses revealed that participants who did not achieve the HbA1c target, as well as men in Cluster 3, had the highest mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even if we identified higher all\u2010cause mortality across the three clusters, our findings highlighted the disproportionate burden of diabetes, particularly among men, as well as the urgent need for targeted and culturally sensitive interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.16644","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:29:49Z","timestamp":1753439389000},"page":"5889-5898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diabetes is one of the main drivers of mortality in Mexico: A latent class analysis of chronic diseases using 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