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While insulin\u2010based therapies have been efficient in reducing hyperglycaemia, they have also been linked with an increased risk of hypoglycaemia, increased treatment burden, and weight gain. The advent of novel classes of antidiabetic agents, such as glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RA) or sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT\u20102i) presents a significant shift in the T2DM treatment algorithms. These medications are not only efficient in the reduction of glycaemia but are also able to reduce weight and have cardiovascular and renal benefits. PwT2DM on complex insulin regimens can now benefit from therapy simplification, taking advantage of once\u2010daily fixed\u2010ratio combinations (FRC) of basal insulin and glucagon\u2010like peptide\u20101 receptor agonist. Current evidence suggests that this approach is equally efficient in terms of glycaemic control with the additional benefit of the reduction of body weight, total daily dose of insulin, and the number of insulin injections administered per day with no increase or reduction of hypoglycaemia. The primary aim of this review is to present the current evidence supporting the simplification of complex insulin regimens in PwT2DM with the two currently available FRCs on the market (insulin glargine 100\u2009U\/mL and GLP\u20101 RA lixisenatide [iGlarLixi] or insulin degludec and GLP\u20101 RA liraglutide [IDegLira]) and to provide a simple clinical practice\u2010oriented algorithm for clinicians based on the currently available evidence.<\/jats:p>","DOI":"10.1111\/dom.16645","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:56:05Z","timestamp":1753710965000},"page":"42-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Practical limitations of complex insulin therapies in type 2 diabetes: Focus on therapy simplification using fixed\u2010ratio combinations of basal insulin and a glucagon\u2010like peptide\u20101 receptor 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