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Patients were required to have \u22651\u2009year of continuous health and pharmacy plan coverage, a diagnosis of overweight or obesity, no prior suicidality or type 2 diabetes, and new users of semaglutide or active comparators for inclusion. SI and suicidality were identified using diagnosis codes within 183\u2009days of drug initiation. Kaplan\u2013Meier analysis was used to estimate risks, risk differences (RDs), and risk ratios (RRs), controlling for confounding with standardized mortality ratio weights.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 16\u2009822 semaglutide and 11\u2009986 active comparator new users, the adjusted risk of incident SI was 0.08% (13.0 events) for semaglutide and 0.05% (8.9 events) for active comparators, and for incident suicidality was 0.08% (14.0 events) for semaglutide and 0.07% (11.0 events) for active comparators. Adjusted RDs were 0.02% (95% CI: [\u22120.02%, 0.07%]) for SI and 0.02% (\u22120.03%, 0.07%) for suicidality, with corresponding RRs of 1.36 (0.62, 6.14) and 1.18 (0.57, 3.63).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients initiating semaglutide for weight management, semaglutide did not appear to increase the risk of suicide\u2010related outcomes. However, the CIs of the RDs are compatible with a 0.07% increase in 6\u2010month risk and the true RD could be larger due to the potentially low sensitivity of ICD\u201010 diagnosis codes for and underreporting of suicide\u2010related outcomes. Additional studies are critical to confirm these findings and obtain more precise estimates of any potential benefits or harms of semaglutide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70002","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:11:45Z","timestamp":1754370705000},"page":"6178-6187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk of suicidal ideation and suicidality among adults prescribed semaglutide for weight management: A population\u2010based cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-1032","authenticated-orcid":false,"given":"Qoua L.","family":"Her","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill North Carolina 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