{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T09:17:03Z","timestamp":1777195023394,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100030680","name":"Fu Jen Catholic University Hospital","doi-asserted-by":"publisher","award":["PL\u2010202408022\u2010V"],"award-info":[{"award-number":["PL\u2010202408022\u2010V"]}],"id":[{"id":"10.13039\/100030680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether initiating sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i) within 3\u2009months after a urinary tract infection (UTI) is associated with improved long\u2010term outcomes in patients with type 2 diabetes mellitus (T2DM), compared with dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using the TriNetX US Collaborative Network (2016\u20132023). Adults with T2DM who initiated SGLT2i or DPP\u20104i within 90\u2009days after a UTI or pyelonephritis diagnosis were identified. Propensity score matching (1:1) was applied to balance baseline covariates. The primary outcome was mortality. Secondary outcomes included major adverse kidney events (MAKE), major adverse cardiovascular events (MACE), hospitalisation, dialysis dependence, emergency department (ED) visits, and sepsis. Outcomes were assessed over a 4\u2010year period using Cox proportional hazards models and Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 2129 patients were included in each group. Compared with DPP\u20104i, SGLT2i use was associated with lower risks of mortality (HR 0.59, 95% CI 0.45\u20130.77), MAKE (HR 0.78), hospitalisation (HR 0.89), dialysis dependence (HR 0.43), sepsis (HR 0.75), and ED visits (HR 0.88). No significant difference was found for MACE (HR 0.91, 95% CI 0.79\u20131.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with T2DM recovering from UTI, the use of SGLT2 inhibitors was associated with lower risks of mortality, kidney complications, and infection\u2010related outcomes compared with DPP\u20104 inhibitors. These findings support the safety and clinical benefit of continuing or initiating SGLT2i during the post\u2010infectious phase, even after a recent urinary tract infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70003","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T10:20:06Z","timestamp":1754302806000},"page":"6188-6199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between sodium\u2010glucose cotransporter 2 inhibitor use and clinical outcomes in patients with type 2 diabetes after urinary tract infection"],"prefix":"10.1111","volume":"27","author":[{"given":"Hsiao\u2010Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Internal Medicine Shin\u2010Kong Wu Ho\u2010Su Memorial Hospital  Taipei 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