{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:15:24Z","timestamp":1780442124371,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Pericoronary adipose tissue (PCAT) attenuation, assessed by coronary computed tomography angiography (CCTA), is a biomarker of coronary inflammation. Mean PCAT attenuation \u2265\u2009\u221270.5 Hounsfield Units (HU) corresponds to elevated inflammation and a higher future risk of myocardial infarction. While statins are known to possess anti\u2010inflammatory properties, the impact of statin intensity on vascular inflammation remains underexplored in patients with type 2 diabetes mellitus (T2DM) and coronary atherosclerosis. We aim to evaluate whether high\u2010intensity statins are associated with lower PCAT attenuation in this high\u2010risk cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 203 CCTAs performed at our institution between 1\/1\/2019 and 9\/1\/2024 in patients with T2DM who met these key criteria: evidence of coronary atherosclerosis on CCTA, treatment with \u22651 oral hypoglycaemic agent, and no history of prior coronary interventions. PCAT attenuation was measured in the proximal right coronary artery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the three statin intensity groups, patients receiving high\u2010intensity statins (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200975) had the lowest PCAT attenuation (high\u2010intensity: \u221275.0\u2009\u00b1\u20096.8 HU, moderate\u2010intensity: \u221271.8\u2009\u00b1\u20098.2 HU, no statin: \u221271.6\u2009\u00b1\u20097.4 HU; adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). In addition to high\u2010intensity statins, treatment with glucagon\u2010like peptide\u20101 receptor agonist was independently associated with a lower likelihood of having elevated PCAT attenuation (\u2265\u2009\u221270.5 HU), with an odds ratio of 0.344 (95% CI: 0.132\u20130.900).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with T2DM and coronary atherosclerosis, high\u2010intensity statin therapy was associated with lower coronary inflammation. Our findings emphasize the need for aggressive cardiovascular prevention in this high\u2010risk cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70032","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T06:01:18Z","timestamp":1755583278000},"page":"6395-6402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010intensity statin therapy is associated with reduced coronary inflammation on\n                    <scp>CT<\/scp>\n                    in patients with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5789-8366","authenticated-orcid":false,"given":"Bryan","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Stanford University  Stanford California 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